Genetic determinants associated with cfxA -positive clinical Capnocytophaga isolates

Sir,Capnocytophaga spp. have a role in the pathogenesis of various forms of periodontal disease and systemic infections, particularly severe in neutropenic cancer patients. The prevalence of β-lactam-resistant oral bacteria is increasing in clinical isolates [1]. All of the reported β-lactam-resista...

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Published in:International journal of antimicrobial agents 2015-09, Vol.46 (3), p.356-358
Main Authors: Tamanai-Shacoori, Zohreh, Dupont, Anais, Auffret, Manon, Peton, Vincent, Barloy-Hubler, Frédérique, Ehrmann, Elodie, Ropert, Martine, Bonnaure-Mallet, Martine, Jolivet-Gougeon, Anne
Format: Article
Language:English
Subjects:
beta-Lactamases - genetics
Capnocytophaga - classification
Capnocytophaga - enzymology
Capnocytophaga - genetics
Capnocytophaga - isolation & purification
Cellular Biology
Gene Expression Profiling
Genes, Bacterial
Genetic Variation
Gram-Negative Bacterial Infections - microbiology
Humans
Infectious Disease
Life Sciences
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Summary:Sir,Capnocytophaga spp. have a role in the pathogenesis of various forms of periodontal disease and systemic infections, particularly severe in neutropenic cancer patients. The prevalence of β-lactam-resistant oral bacteria is increasing in clinical isolates [1]. All of the reported β-lactam-resistant Capnocytophaga isolates are β-lactamase-producers, but minimum inhibitory concentrations (MICs) for the different β-lactams are variable [2]. The objective of the current study was therefore to explain the variability in β-lactam MIC profiles in 31 cfxA gene-positive oral Capnocytophaga spp. clinical isolates with various antibiotypes...
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2015.05.006