Detection of Drug–Drug Interactions Inducing Acute Kidney Injury by Electronic Health Records Mining

• Published in: Drug safety 2015-09, Vol.38 (9), p.799-809
• Main Authors: Girardeau, Yannick, Trivin, Claire, Durieux, Pierre, Le Beller, Christine, Louet Agnes, Lillo-Le, Neuraz, Antoine, Degoulet, Patrice, Avillach, Paul
• Format: Article
• Language: English
• Subjects: Data mining; Drug Safety and Pharmacovigilance; Electronic health records; Funding; Hospitalization; Human health and pathology; Life Sciences; Medicine; Medicine & Public Health; Mortality; Original Research Article; Pharmaceutical sciences; Pharmacology/Toxicology; Studies; Urology and Nephrology
• ISSN: 0114-5916; 1179-1942
• DOI: 10.1007/s40264-015-0311-y

Background and Objective While risk of acute kidney injury (AKI) is a well documented adverse effect of some drugs, few studies have assessed the relationship between drug–drug interactions (DDIs) and AKI. Our objective was to develop an algorithm capable of detecting potential signals on this relationship by retrospectively mining data from electronic health records. Material and methods Data were extracted from the clinical data warehouse (CDW) of the Hôpital Européen Georges Pompidou (HEGP). AKI was defined as the first level of the RIFLE criteria, that is, an increase ≥50 % of creatinine basis. Algorithm accuracy was tested on 20 single drugs, 10 nephrotoxic and 10 non-nephrotoxic. We then tested 45 pairs of non-nephrotoxic drugs, among the most prescribed at our hospital and representing distinct pharmacological classes for DDIs. Results Sensitivity and specificity were 50 % [95 % confidence interval (CI) 23.66–76.34] and 90 % (95 % CI 59.58–98.21), respectively, for single drugs. Our algorithm confirmed a previously identified signal concerning clarithromycin and calcium-channel blockers (unadjusted odds ratio (ORu) 2.92; 95 % CI 1.11–7.69, p  = 0.04). Among the 45 drug pairs investigated, we identified a signal concerning 55 patients in association with bromazepam and hydroxyzine (ORu 1.66; 95 % CI 1.23–2.23). This signal was not confirmed after a chart review. Even so, AKI and co-prescription were confirmed for 96 % (95 % CI 88–99) and 88 % (95 % CI 76–94) of these patients, respectively. Conclusion Data mining techniques on CDW can foster the detection of adverse drug reactions when drugs are used alone or in combination.