Renal Resistive Index in 55 Dogs with Degenerative Mitral Valve Disease

Background Azotemia occurs frequently in dogs with degenerative mitral valve disease (DMVD). It could indicate changes in renal hemodynamics. Hypothesis/Objectives To assess the renal resistive index (RI) in dogs with DMVD, and the statistical link between heart failure class, azotemia, echo‐Doppler...

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Bibliographic Details
Published in:Journal of veterinary internal medicine 2012-01, Vol.26 (1), p.101-108
Main Authors: Chetboul, V., Daste, T., Gouni, V., Concordet, D., Trehiou‐Sechi, E., Serres, F., Pouchelon, J.L., Germain, C.A., Layssol‐Lamour, C., Lefebvre, H.P.
Format: Article
Language:English
Subjects:
Animals
Azotemia
Azotemia - diagnostic imaging
Azotemia - physiopathology
Azotemia - veterinary
Canine
Creatinine - blood
Dog Diseases - blood
Dog Diseases - diagnostic imaging
Dog Diseases - physiopathology
Dogs
Echocardiography - veterinary
Female
Heart failure
Heart Valve Diseases - blood
Heart Valve Diseases - diagnostic imaging
Heart Valve Diseases - physiopathology
Heart Valve Diseases - veterinary
Kidney
Life Sciences
Male
Mitral Valve - diagnostic imaging
Mitral Valve - physiopathology
Natriuretic Peptide, Brain - blood
Peptide Fragments - blood
Prospective Studies
Regression Analysis
Ultrasonography
Urea - blood
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Summary:Background Azotemia occurs frequently in dogs with degenerative mitral valve disease (DMVD). It could indicate changes in renal hemodynamics. Hypothesis/Objectives To assess the renal resistive index (RI) in dogs with DMVD, and the statistical link between heart failure class, azotemia, echo‐Doppler parameters, several plasma variables, and RI. Animals Fifty‐five dogs with naturally occurring DVMD were used (ISACHC class 1 [n = 28], 2 [n = 19], and 3 [n = 8]). Methods Observational, blinded study, performed under standardized conditions. Physical examination, renal ultrasonography, and echo‐Doppler examinations were performed in awake dogs. The RI of the renal, interlobar, and arcuate arteries were measured. Plasma creatinine, urea, and N‐terminal pro‐B‐type natriuretic peptide concentrations (NT‐proBNP) were determined. Statistical links between variables and RI were tested by means of a general linear model. Results Although the RI of renal and arcuate arteries were unaffected by ISACHC class, the left interlobar RI increased (P 
ISSN:0891-6640
1939-1676
DOI:10.1111/j.1939-1676.2011.00840.x