Influence of blood pressure and vascular resistance on the response to medications lowering intraocular pressure: a mathematical model

Elevated intraocular pressure (IOP) can be reduced via medications modulating aqueous humor (AH) flow, but the drug efficacy varies significantly among patients. Many factors may influence drug efficacy, including mean arterial pressure (MAP) and systemic vascular resistance (sVR). Here we propose a...

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Bibliographic Details
Published in:Investigative ophthalmology & visual science 2015-06, Vol.56 (7)
Main Authors: Guidoboni, G., Harris, Alon, Prud'Homme, Christophe, Siesky, Brent, Sacco, Riccardo, Szopos, Marcela
Format: Article
Language:English
Subjects:
Human health and pathology
Life Sciences
Mathematics
Online Access:Get full text
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Summary:Elevated intraocular pressure (IOP) can be reduced via medications modulating aqueous humor (AH) flow, but the drug efficacy varies significantly among patients. Many factors may influence drug efficacy, including mean arterial pressure (MAP) and systemic vascular resistance (sVR). Here we propose a mathematical model to theoretically investigate the individual roles played by MAP and sVR on the response to IOP-lowering medications.
ISSN:0146-0404
1552-5783