Fatigue of Metallic Stents: From Clinical Evidence to Computational Analysis

The great success of stents in treating cardiovascular disease is actually undermined by their long-term fatigue failure. The high variability of stent failure incidence suggests that it is due to several correlated aspects, such as loading conditions, material properties, component design, surgical...

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Bibliographic Details
Published in:Annals of biomedical engineering 2016-02, Vol.44 (2), p.287-301
Main Authors: Auricchio, F., Constantinescu, A., Conti, M., Scalet, G.
Format: Article
Language:English
Subjects:
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
Biophysics
Cardiovascular diseases
Cardiovascular Diseases - surgery
Classical Mechanics
Computation
Design analysis
Design engineering
Fatigue
Fatigue (materials)
Fatigue failure
Humans
Materials and structures in mechanics
Mathematical models
Mechanics
Medical Stents: State of the Art and Future Directions
Models, Theoretical
Physics
Stents
Stress, Mechanical
Surgical implants
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Summary:The great success of stents in treating cardiovascular disease is actually undermined by their long-term fatigue failure. The high variability of stent failure incidence suggests that it is due to several correlated aspects, such as loading conditions, material properties, component design, surgical procedure, and patient functional anatomy. Numerical and experimental non-clinical assessments are included in the recommendations and requirements of several regulatory bodies and they are thus exploited in the analysis of stent fatigue performance. Optimization-based simulation methodologies have been developed as well, to improve the fatigue endurance of novel designs. This paper presents a review on the fatigue issue in metallic stents, starting from a description of clinical evidence about stent fracture up to the analysis of computational approaches available from the literature. The reported discussion on both the experimental and numerical framework aims at providing a general insight into stent lifetime prediction as well as at understanding the factors which affect stent fatigue performance for the design of novel components.
ISSN:0090-6964
1573-9686
DOI:10.1007/s10439-015-1447-8