Fatty Acid Metabolism Meets Organelle Dynamics

Upon nutrient deprivation, cells metabolize fatty acids (FAs) in mitochondria to supply energy, but how FAs, stored as triacylglycerols in lipid droplets, reach mitochondria has been mysterious. Rambold et al. (2015) now show that FA mobilization depends on triacylglycerol lipolysis, whereas autopha...

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Bibliographic Details
Published in:Developmental cell 2015-03, Vol.32 (6), p.657-658
Main Authors: Walch, Laurence, Čopič, Alenka, Jackson, Catherine L.
Format: Article
Language:English
Subjects:
Animals
Autophagy
Autophagy - physiology
Cellular Biology
Development Biology
Fatty Acids
Fatty Acids - metabolism
Life Sciences
Lipolysis
Lipolysis - physiology
Mitochondrial Dynamics
Mitochondrial Dynamics - physiology
Starvation
Starvation - metabolism
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Summary:Upon nutrient deprivation, cells metabolize fatty acids (FAs) in mitochondria to supply energy, but how FAs, stored as triacylglycerols in lipid droplets, reach mitochondria has been mysterious. Rambold et al. (2015) now show that FA mobilization depends on triacylglycerol lipolysis, whereas autophagy feeds the lipid droplet pool for continued fueling of mitochondria.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2015.03.008