Secondary Metabolites Isolated from the Amazonian Endophytic Fungus Diaporthe sp. SNB-GSS10

We describe a Sabicea cinerea endophytic fungus closely related to Diaporthe pseudomangiferae that produces two known metabolites, mycoepoxydiene (1) and altiloxin A (2), as well as enamidin (3) and eremofortin F (4), two compounds not previously described in the literature. The structure of these f...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2015-07, Vol.78 (7), p.1735-1739
Main Authors: Mandavid, Hugues, Rodrigues, Alice M. S, Espindola, Laila S, Eparvier, Véronique, Stien, Didier
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Ascomycota - chemistry
Bridged-Ring Compounds - chemistry
Bridged-Ring Compounds - isolation & purification
Bridged-Ring Compounds - pharmacology
Chemical Sciences
Drug Screening Assays, Antitumor
Endophytes - chemistry
Humans
KB Cells
Molecular Structure
Pyrones - chemistry
Pyrones - isolation & purification
Pyrones - pharmacology
Sesquiterpenes - chemistry
Sesquiterpenes - isolation & purification
Sesquiterpenes - pharmacology
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Summary:We describe a Sabicea cinerea endophytic fungus closely related to Diaporthe pseudomangiferae that produces two known metabolites, mycoepoxydiene (1) and altiloxin A (2), as well as enamidin (3) and eremofortin F (4), two compounds not previously described in the literature. The structure of these four metabolites was elucidated using spectroscopic analysis, and their cytotoxic activities were measured against the human cell lines KB, MRC-5, and MDA-MB-435.
ISSN:0163-3864
1520-6025
DOI:10.1021/np501029s