Evolution of ideas and techniques, and future prospects in epilepsy surgery

• Published in: Revue neurologique 2015-02, Vol.171 (2), p.141-156
• Main Authors: Mathon, B, Bédos-Ulvin, L, Baulac, M, Dupont, S, Navarro, V, Carpentier, A, Cornu, P, Clemenceau, S
• Format: Article
• Language: fre
• Subjects: Bioengineering; Biomedical Research; Biomedical Research - trends; Child; Computer Science; Computer Vision and Pattern Recognition; Deep Brain Stimulation; Engineering Sciences; Epilepsy; Epilepsy - epidemiology; Epilepsy - etiology; Epilepsy - surgery; Hamartoma; Hamartoma - complications; Hamartoma - epidemiology; Hamartoma - surgery; Humans; Hypothalamic Diseases; Hypothalamic Diseases - complications; Hypothalamic Diseases - epidemiology; Hypothalamic Diseases - surgery; Image Processing; Imaging; Life Sciences; Medical Imaging; Neurobiology; Neurons and Cognition; Neurosurgical Procedures; Neurosurgical Procedures - methods; Neurosurgical Procedures - statistics & numerical data; Neurosurgical Procedures - trends; Radiosurgery; Radiosurgery - statistics & numerical data; Signal and Image processing; Temporal Lobe; Temporal Lobe - surgery; Treatment Outcome
• ISSN: 0035-3787
• DOI: 10.1016/j.neurol.2014.09.010

The aim of this article was to review and evaluate the published literature related to the outcome of epilepsy surgery, while placing it in an historical perspective, and to describe the future prospects in this field. Temporal lobe surgery achieves seizure freedom in about 70% of cases. Seizure outcome is similar in the pediatric population. Extratemporal resections impart good results to 40% to 60% of patients, with a better prognosis in the case of frontal lobe surgery. Pediatric hemispherotomy leads to seizure control in about 80% of children. Radiosurgery used as a treatment for temporal mesial epilepsy has an outcome quite similar to that obtained with surgical resection, but provides a neuropsychological advantage. Radiosurgery is also effective in 60% of children treated for seizures related to hypothalamic hamartoma. Regarding palliative surgery, callosotomy and multiple subpial transections show satisfactory outcomes in over 60% of cases. Neuromodulation techniques (vagus nerve stimulation and bilateral stimulation of the anterior nucleus of the thalamus) allow a 50% reduction of seizures in half of patients. Transcranial magnetic stimulation combined with electroencephalography seems a promising technique because of its diagnostic, prognostic and therapeutic applications. Transcranial ultrasound stimulation, which can reversibly control neuronal activity, is also under consideration. Concerning neuromodulation, trigeminal nerve stimulation may become an alternative to vagus nerve stimulation; while other targets of deep brain stimulation are being evaluated. Also, the possibility of coupling SEEG seizure focus detection with concomitant laser or radiofrequency focus destruction is under development. Constant evolution of epilepsy surgery has improved patient outcomes over time. Current research and development axes suggest the continuation of this trend and a reduction of the invasiveness of surgical procedures.