Early Fiber Number Ratio Is a Surrogate of Corticospinal Tract Integrity and Predicts Motor Recovery After Stroke

• Published in: Stroke (1970) 2016-04, Vol.47 (4), p.1053-1059
• Main Authors: Bigourdan, Antoine, Munsch, Fanny, Coupé, Pierrick, Guttmann, Charles R.G, Sagnier, Sharmila, Renou, Pauline, Debruxelles, Sabrina, Poli, Mathilde, Dousset, Vincent, Sibon, Igor, Tourdias, Thomas
• Format: Article
• Language: English
• Subjects: Aged; Brain Ischemia - diagnosis; Brain Ischemia - physiopathology; Computer Science; Diffusion Tensor Imaging; Female; Humans; Male; Medical Imaging; Middle Aged; Motor Activity - physiology; Predictive Value of Tests; Prognosis; Pyramidal Tracts - physiopathology; Recovery of Function - physiology; Severity of Illness Index; Stroke - diagnosis; Stroke - physiopathology
• ISSN: 0039-2499; 1524-4628
• DOI: 10.1161/STROKEAHA.115.011576

BACKGROUND AND PURPOSE—The contribution of imaging metrics to predict poststroke motor recovery needs to be clarified. We tested the added value of early diffusion tensor imaging (DTI) of the corticospinal tract toward predicting long-term motor recovery. METHODS—One hundred seventeen patients were prospectively assessed at 24 to 72 hours and 1 year after ischemic stroke with diffusion tensor imaging and motor scores (Fugl-Meyer). The initial fiber number ratio (iFNr) and final fiber number ratio were computed as the number of streamlines along the affected corticospinal tract normalized to the unaffected side and were compared with each other. The prediction of motor recovery (ΔFugl-Meyer) was first modeled using initial Fugl-Meyer and iFNr. Multivariate ordinal logistic regression models were also used to study the association of iFNr, initial Fugl-Meyer, age, and stroke volume with Fugl-Meyer at 1 year. RESULTS—The iFNr correlated with the final fiber number ratio at 1 year (r=0.70; P