Solid Lipid Nanoparticles for Image-Guided Therapy of Atherosclerosis

Although the application of nanotechnologies to atherosclerosis remains a young field, novel strategies are needed to address this public health issue. In this context, the magnetic resonance imaging (MRI) approach has been gradually investigated in order to enable image-guided treatments. In this c...

Full description

Saved in:
Bibliographic Details
Published in:Bioconjugate chemistry 2016-03, Vol.27 (3), p.569-575
Main Authors: Oumzil, Khalid, Ramin, Michael A, Lorenzato, Cyril, Hémadou, Audrey, Laroche, Jeanny, Jacobin-Valat, Marie Josée, Mornet, Stephane, Roy, Claude-Eric, Kauss, Tina, Gaudin, Karen, Clofent-Sanchez, Gisèle, Barthélémy, Philippe
Format: Article
Language:English
Subjects:
Atherosclerosis
Atherosclerosis - therapy
Chemical Sciences
Epoprostenol - administration & dosage
Epoprostenol - therapeutic use
Lipids
Lipids - chemistry
Magnetic Resonance Imaging - methods
Material chemistry
Medical procedures
Nanoparticles
NMR
Nuclear magnetic resonance
Solids
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-a468t-d25d59b86000d1c8ff81a9d64b12f11b1b5830aefeb871ff17de93f257a0ced53
cites cdi_FETCH-LOGICAL-a468t-d25d59b86000d1c8ff81a9d64b12f11b1b5830aefeb871ff17de93f257a0ced53
container_end_page 575
container_issue 3
container_start_page 569
container_title Bioconjugate chemistry
container_volume 27
creator Oumzil, Khalid
Ramin, Michael A
Lorenzato, Cyril
Hémadou, Audrey
Laroche, Jeanny
Jacobin-Valat, Marie Josée
Mornet, Stephane
Roy, Claude-Eric
Kauss, Tina
Gaudin, Karen
Clofent-Sanchez, Gisèle
Barthélémy, Philippe
description Although the application of nanotechnologies to atherosclerosis remains a young field, novel strategies are needed to address this public health issue. In this context, the magnetic resonance imaging (MRI) approach has been gradually investigated in order to enable image-guided treatments. In this contribution, we report a new approach based on nucleoside-lipids allowing the synthesis of solid lipid nanoparticles (SLN) loaded with iron oxide particles and therapeutic agents. The insertion of nucleoside-lipids allows the formation of stable SLNs loaded with prostacycline (PGI2) able to inhibit platelet aggregation. The new SLNs feature better relaxivity properties in comparison to the clinically used contrast agent Feridex, indicating that SLNs are suitable for image-guided therapy.
doi_str_mv 10.1021/acs.bioconjchem.5b00590
format article
fullrecord <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_01296329v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1774162186</sourcerecordid><originalsourceid>FETCH-LOGICAL-a468t-d25d59b86000d1c8ff81a9d64b12f11b1b5830aefeb871ff17de93f257a0ced53</originalsourceid><addsrcrecordid>eNqFkU1PwzAMhiMEYuPjL0AlLnDoiNOmSY7TND6kCQ6Mc5Q2CcvULqVZkfj3ZNoYiAsX27Iev7b1InQJeASYwK2qwqh0vvKrZbUwzYiWGFOBD9AQKMFpzoEcxhrnWQockwE6CWGJMRbAyTEakIJREIIN0fTF104nM9fG-KRWvlXd2lW1CYn1XfLYqDeT3vdOG53MF6ZT7WfibTJex9qHyMXowhk6sqoO5nyXT9Hr3XQ-eUhnz_ePk_EsVXnB16kmVFNR8iJeoqHi1nJQQhd5CcQClFBSnmFlrCk5A2uBaSMySyhTuDKaZqfoZqu7ULVsO9eo7lN65eTDeCY3PQxEFBkRHxDZ6y3bdv69N2EtGxcqU9dqZXwfJDCWQ0GAFxG9-oMufd-t4icbirNC5JxFim2pKv4cOmP3FwCWG1dkdEX-ckXuXImTFzv9vmyM3s992xCBbAtsFH52_yP7BWABnSY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1778769487</pqid></control><display><type>article</type><title>Solid Lipid Nanoparticles for Image-Guided Therapy of Atherosclerosis</title><source>American Chemical Society:Jisc Collections:American Chemical Society Read &amp; Publish Agreement 2022-2024 (Reading list)</source><creator>Oumzil, Khalid ; Ramin, Michael A ; Lorenzato, Cyril ; Hémadou, Audrey ; Laroche, Jeanny ; Jacobin-Valat, Marie Josée ; Mornet, Stephane ; Roy, Claude-Eric ; Kauss, Tina ; Gaudin, Karen ; Clofent-Sanchez, Gisèle ; Barthélémy, Philippe</creator><creatorcontrib>Oumzil, Khalid ; Ramin, Michael A ; Lorenzato, Cyril ; Hémadou, Audrey ; Laroche, Jeanny ; Jacobin-Valat, Marie Josée ; Mornet, Stephane ; Roy, Claude-Eric ; Kauss, Tina ; Gaudin, Karen ; Clofent-Sanchez, Gisèle ; Barthélémy, Philippe</creatorcontrib><description>Although the application of nanotechnologies to atherosclerosis remains a young field, novel strategies are needed to address this public health issue. In this context, the magnetic resonance imaging (MRI) approach has been gradually investigated in order to enable image-guided treatments. In this contribution, we report a new approach based on nucleoside-lipids allowing the synthesis of solid lipid nanoparticles (SLN) loaded with iron oxide particles and therapeutic agents. The insertion of nucleoside-lipids allows the formation of stable SLNs loaded with prostacycline (PGI2) able to inhibit platelet aggregation. The new SLNs feature better relaxivity properties in comparison to the clinically used contrast agent Feridex, indicating that SLNs are suitable for image-guided therapy.</description><identifier>ISSN: 1043-1802</identifier><identifier>EISSN: 1520-4812</identifier><identifier>DOI: 10.1021/acs.bioconjchem.5b00590</identifier><identifier>PMID: 26751997</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Atherosclerosis ; Atherosclerosis - therapy ; Chemical Sciences ; Epoprostenol - administration &amp; dosage ; Epoprostenol - therapeutic use ; Lipids ; Lipids - chemistry ; Magnetic Resonance Imaging - methods ; Material chemistry ; Medical procedures ; Nanoparticles ; NMR ; Nuclear magnetic resonance ; Solids</subject><ispartof>Bioconjugate chemistry, 2016-03, Vol.27 (3), p.569-575</ispartof><rights>Copyright © 2016 American Chemical Society</rights><rights>Copyright American Chemical Society Mar 16, 2016</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a468t-d25d59b86000d1c8ff81a9d64b12f11b1b5830aefeb871ff17de93f257a0ced53</citedby><cites>FETCH-LOGICAL-a468t-d25d59b86000d1c8ff81a9d64b12f11b1b5830aefeb871ff17de93f257a0ced53</cites><orcidid>0000-0003-3917-0579 ; 0000-0002-0755-145X ; 0000-0003-1583-7180 ; 0000-0002-1115-5812</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26751997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01296329$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Oumzil, Khalid</creatorcontrib><creatorcontrib>Ramin, Michael A</creatorcontrib><creatorcontrib>Lorenzato, Cyril</creatorcontrib><creatorcontrib>Hémadou, Audrey</creatorcontrib><creatorcontrib>Laroche, Jeanny</creatorcontrib><creatorcontrib>Jacobin-Valat, Marie Josée</creatorcontrib><creatorcontrib>Mornet, Stephane</creatorcontrib><creatorcontrib>Roy, Claude-Eric</creatorcontrib><creatorcontrib>Kauss, Tina</creatorcontrib><creatorcontrib>Gaudin, Karen</creatorcontrib><creatorcontrib>Clofent-Sanchez, Gisèle</creatorcontrib><creatorcontrib>Barthélémy, Philippe</creatorcontrib><title>Solid Lipid Nanoparticles for Image-Guided Therapy of Atherosclerosis</title><title>Bioconjugate chemistry</title><addtitle>Bioconjugate Chem</addtitle><description>Although the application of nanotechnologies to atherosclerosis remains a young field, novel strategies are needed to address this public health issue. In this context, the magnetic resonance imaging (MRI) approach has been gradually investigated in order to enable image-guided treatments. In this contribution, we report a new approach based on nucleoside-lipids allowing the synthesis of solid lipid nanoparticles (SLN) loaded with iron oxide particles and therapeutic agents. The insertion of nucleoside-lipids allows the formation of stable SLNs loaded with prostacycline (PGI2) able to inhibit platelet aggregation. The new SLNs feature better relaxivity properties in comparison to the clinically used contrast agent Feridex, indicating that SLNs are suitable for image-guided therapy.</description><subject>Atherosclerosis</subject><subject>Atherosclerosis - therapy</subject><subject>Chemical Sciences</subject><subject>Epoprostenol - administration &amp; dosage</subject><subject>Epoprostenol - therapeutic use</subject><subject>Lipids</subject><subject>Lipids - chemistry</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Material chemistry</subject><subject>Medical procedures</subject><subject>Nanoparticles</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Solids</subject><issn>1043-1802</issn><issn>1520-4812</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFkU1PwzAMhiMEYuPjL0AlLnDoiNOmSY7TND6kCQ6Mc5Q2CcvULqVZkfj3ZNoYiAsX27Iev7b1InQJeASYwK2qwqh0vvKrZbUwzYiWGFOBD9AQKMFpzoEcxhrnWQockwE6CWGJMRbAyTEakIJREIIN0fTF104nM9fG-KRWvlXd2lW1CYn1XfLYqDeT3vdOG53MF6ZT7WfibTJex9qHyMXowhk6sqoO5nyXT9Hr3XQ-eUhnz_ePk_EsVXnB16kmVFNR8iJeoqHi1nJQQhd5CcQClFBSnmFlrCk5A2uBaSMySyhTuDKaZqfoZqu7ULVsO9eo7lN65eTDeCY3PQxEFBkRHxDZ6y3bdv69N2EtGxcqU9dqZXwfJDCWQ0GAFxG9-oMufd-t4icbirNC5JxFim2pKv4cOmP3FwCWG1dkdEX-ckXuXImTFzv9vmyM3s992xCBbAtsFH52_yP7BWABnSY</recordid><startdate>20160316</startdate><enddate>20160316</enddate><creator>Oumzil, Khalid</creator><creator>Ramin, Michael A</creator><creator>Lorenzato, Cyril</creator><creator>Hémadou, Audrey</creator><creator>Laroche, Jeanny</creator><creator>Jacobin-Valat, Marie Josée</creator><creator>Mornet, Stephane</creator><creator>Roy, Claude-Eric</creator><creator>Kauss, Tina</creator><creator>Gaudin, Karen</creator><creator>Clofent-Sanchez, Gisèle</creator><creator>Barthélémy, Philippe</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0003-3917-0579</orcidid><orcidid>https://orcid.org/0000-0002-0755-145X</orcidid><orcidid>https://orcid.org/0000-0003-1583-7180</orcidid><orcidid>https://orcid.org/0000-0002-1115-5812</orcidid></search><sort><creationdate>20160316</creationdate><title>Solid Lipid Nanoparticles for Image-Guided Therapy of Atherosclerosis</title><author>Oumzil, Khalid ; Ramin, Michael A ; Lorenzato, Cyril ; Hémadou, Audrey ; Laroche, Jeanny ; Jacobin-Valat, Marie Josée ; Mornet, Stephane ; Roy, Claude-Eric ; Kauss, Tina ; Gaudin, Karen ; Clofent-Sanchez, Gisèle ; Barthélémy, Philippe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a468t-d25d59b86000d1c8ff81a9d64b12f11b1b5830aefeb871ff17de93f257a0ced53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Atherosclerosis</topic><topic>Atherosclerosis - therapy</topic><topic>Chemical Sciences</topic><topic>Epoprostenol - administration &amp; dosage</topic><topic>Epoprostenol - therapeutic use</topic><topic>Lipids</topic><topic>Lipids - chemistry</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Material chemistry</topic><topic>Medical procedures</topic><topic>Nanoparticles</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Solids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oumzil, Khalid</creatorcontrib><creatorcontrib>Ramin, Michael A</creatorcontrib><creatorcontrib>Lorenzato, Cyril</creatorcontrib><creatorcontrib>Hémadou, Audrey</creatorcontrib><creatorcontrib>Laroche, Jeanny</creatorcontrib><creatorcontrib>Jacobin-Valat, Marie Josée</creatorcontrib><creatorcontrib>Mornet, Stephane</creatorcontrib><creatorcontrib>Roy, Claude-Eric</creatorcontrib><creatorcontrib>Kauss, Tina</creatorcontrib><creatorcontrib>Gaudin, Karen</creatorcontrib><creatorcontrib>Clofent-Sanchez, Gisèle</creatorcontrib><creatorcontrib>Barthélémy, Philippe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Bioconjugate chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oumzil, Khalid</au><au>Ramin, Michael A</au><au>Lorenzato, Cyril</au><au>Hémadou, Audrey</au><au>Laroche, Jeanny</au><au>Jacobin-Valat, Marie Josée</au><au>Mornet, Stephane</au><au>Roy, Claude-Eric</au><au>Kauss, Tina</au><au>Gaudin, Karen</au><au>Clofent-Sanchez, Gisèle</au><au>Barthélémy, Philippe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Solid Lipid Nanoparticles for Image-Guided Therapy of Atherosclerosis</atitle><jtitle>Bioconjugate chemistry</jtitle><addtitle>Bioconjugate Chem</addtitle><date>2016-03-16</date><risdate>2016</risdate><volume>27</volume><issue>3</issue><spage>569</spage><epage>575</epage><pages>569-575</pages><issn>1043-1802</issn><eissn>1520-4812</eissn><abstract>Although the application of nanotechnologies to atherosclerosis remains a young field, novel strategies are needed to address this public health issue. In this context, the magnetic resonance imaging (MRI) approach has been gradually investigated in order to enable image-guided treatments. In this contribution, we report a new approach based on nucleoside-lipids allowing the synthesis of solid lipid nanoparticles (SLN) loaded with iron oxide particles and therapeutic agents. The insertion of nucleoside-lipids allows the formation of stable SLNs loaded with prostacycline (PGI2) able to inhibit platelet aggregation. The new SLNs feature better relaxivity properties in comparison to the clinically used contrast agent Feridex, indicating that SLNs are suitable for image-guided therapy.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>26751997</pmid><doi>10.1021/acs.bioconjchem.5b00590</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-3917-0579</orcidid><orcidid>https://orcid.org/0000-0002-0755-145X</orcidid><orcidid>https://orcid.org/0000-0003-1583-7180</orcidid><orcidid>https://orcid.org/0000-0002-1115-5812</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1043-1802
ispartof Bioconjugate chemistry, 2016-03, Vol.27 (3), p.569-575
issn 1043-1802
1520-4812
language eng
recordid cdi_hal_primary_oai_HAL_hal_01296329v1
source American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects Atherosclerosis
Atherosclerosis - therapy
Chemical Sciences
Epoprostenol - administration & dosage
Epoprostenol - therapeutic use
Lipids
Lipids - chemistry
Magnetic Resonance Imaging - methods
Material chemistry
Medical procedures
Nanoparticles
NMR
Nuclear magnetic resonance
Solids
title Solid Lipid Nanoparticles for Image-Guided Therapy of Atherosclerosis
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T16%3A26%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Solid%20Lipid%20Nanoparticles%20for%20Image-Guided%20Therapy%20of%20Atherosclerosis&rft.jtitle=Bioconjugate%20chemistry&rft.au=Oumzil,%20Khalid&rft.date=2016-03-16&rft.volume=27&rft.issue=3&rft.spage=569&rft.epage=575&rft.pages=569-575&rft.issn=1043-1802&rft.eissn=1520-4812&rft_id=info:doi/10.1021/acs.bioconjchem.5b00590&rft_dat=%3Cproquest_hal_p%3E1774162186%3C/proquest_hal_p%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-a468t-d25d59b86000d1c8ff81a9d64b12f11b1b5830aefeb871ff17de93f257a0ced53%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1778769487&rft_id=info:pmid/26751997&rfr_iscdi=true