Functional coupling of diverse voltage‐gated Ca 2+ channels underlies high fidelity of fast dendritic Ca 2+ signals during burst firing

In neurons, the Ca 2+ signal associated with the dendritic back‐propagating action potential codes a chemical message to the different dendritic sites, playing a crucial role in electrical signalling, synaptic transmission and synaptic plasticity. The study of the underlying Ca 2+ current, mediated...

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Bibliographic Details
Published in:The Journal of physiology 2016-02, Vol.594 (4), p.967-983
Main Authors: Jaafari, Nadia, Canepari, Marco
Format: Article
Language:English
Subjects:
Life Sciences
Neurobiology
Neurons and Cognition
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Summary:In neurons, the Ca 2+ signal associated with the dendritic back‐propagating action potential codes a chemical message to the different dendritic sites, playing a crucial role in electrical signalling, synaptic transmission and synaptic plasticity. The study of the underlying Ca 2+ current, mediated by different types of voltage‐gated Ca 2+ channels, cannot be achieved by using the patch clamp technique. In this article, we used a recently developed cutting‐edge optical technique to investigate the physiological behaviour of local Ca 2+ currents along the apical dendrite of CA1 hippocampal pyramidal neurons. We directly measure, for the first time, the synergistic activation and deactivation of the diverse dendritic voltage‐gated Ca 2+ channels operating during bursts of back‐propagating action potentials to precisely control the Ca 2+ signal. We demonstrate that the Ca 2+ loss via high‐voltage‐activated channels is compensated by the Ca 2+ entry via the other channels translating in high fidelity of Ca 2+ signalling.
ISSN:0022-3751
1469-7793
DOI:10.1113/JP271830