A Fluorescent Polymer Probe with High Selectivity toward Vascular Endothelial Cells for and beyond Noninvasive Two-Photon Intravital Imaging of Brain Vasculature

A chromophore-engineering strategy that relies on the introduction of a ground-state distortion in a quadrupolar chromophore was used to obtain a quasi-quadrupolar chromophore with red emission and large two-photon absorption (2PA) cross-section in polar solvents. This molecule was functionalized wi...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2016-07, Vol.8 (27), p.17047-17059
Main Authors: Mettra, B, Appaix, F, Olesiak-Banska, J, Le Bahers, T, Leung, A, Matczyszyn, K, Samoc, M, van der Sanden, B, Monnereau, C, Andraud, C
Format: Article
Language:English
Subjects:
Catalysis
Chemical Sciences
Inorganic chemistry
Material chemistry
Organic chemistry
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Summary:A chromophore-engineering strategy that relies on the introduction of a ground-state distortion in a quadrupolar chromophore was used to obtain a quasi-quadrupolar chromophore with red emission and large two-photon absorption (2PA) cross-section in polar solvents. This molecule was functionalized with water-solubilizing polymer chains. It constitutes not only a remarkable contrast agent for intravital two-photon microscopy of the functional cerebral vasculature in a minimally invasive configuration but presents intriguing endothelial staining ability that makes it a valuable probe for premortem histological staining.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.6b02936