Microparticles in Angiogenesis: Therapeutic Potential

Considered during the past decades as cell dust, microparticles are now deemed true biomarkers and vectors of biological information between cells. Depending on their origin, the composition of microparticles varies and the subsequent message transported by them, such as proteins, mRNA, or miRNA, ca...

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Bibliographic Details
Published in:Circulation research 2011-06, Vol.109 (1), p.110-119
Main Authors: Martinez, M Carmen, Andriantsitohaina, Ramaroson
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell-Derived Microparticles - physiology
Endothelial Cells - cytology
Endothelial Cells - physiology
Exosomes - physiology
Fundamental and applied biological sciences. Psychology
Humans
Life Sciences
Metabolic Diseases - physiopathology
Neoplasms - blood supply
Neovascularization, Pathologic - etiology
Neovascularization, Physiologic - physiology
Stem Cells - physiology
Vertebrates: cardiovascular system
Citations: Items that this one cites
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Summary:Considered during the past decades as cell dust, microparticles are now deemed true biomarkers and vectors of biological information between cells. Depending on their origin, the composition of microparticles varies and the subsequent message transported by them, such as proteins, mRNA, or miRNA, can differ. Recent studies have described microparticles as “cargos” of deleterious information in blood vessel wall under pathological situations such as hypertension, myocardial infarction, and metabolic syndrome. In addition, it has been reported that depending on their origin, microparticles also possess a therapeutic potential regarding angiogenesis. Microparticles can act directly through the interaction ligand/receptor or indirectly on angiogenesis by modulating soluble factor production involved in endothelial cell differentiation, proliferation, migration, and adhesion; by reprogramming endothelial mature cells; and by inducing changes in levels, phenotype, and function of endothelial progenitor cells. This results in an increase in formation of in vitro capillary-like tubes and the generation of new vessels in vivo under ischemic conditions, for instance. Taking into consideration these properties of microparticles, recent evidence provides new basis to expand the possibility that microparticles might be used as therapeutic tools in pathologies associated with an alteration of angiogenesis.
ISSN:0009-7330
1524-4571
DOI:10.1161/CIRCRESAHA.110.233049