Copper(I) targeting in the Alzheimer's disease context: a first example using the biocompatible PTA ligand

Copper(I) coordinating ligands in the Alzheimer's disease context have remained unexplored, despite the biological relevance of this redox state of the copper ion. Here, we show that the PTA ligand can remove copper from Aβ, prevent reactive oxygen species production and oligomer formation, two...

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Published in:Metallomics 2015-08, Vol.7 (8), p.1229-1232
Main Authors: Atrián-Blasco, E, Cerrada, E, Conte-Daban, A, Testemale, D, Faller, P, Laguna, M, Hureau, C
Format: Article
Language:English
Subjects:
Adamantane - analogs & derivatives
Adamantane - pharmacology
Alzheimer Disease - drug therapy
Alzheimer Disease - metabolism
Amyloid beta-Peptides - chemistry
Amyloid beta-Peptides - metabolism
Copper - isolation & purification
Copper - metabolism
Humans
Life Sciences
Organophosphorus Compounds - pharmacology
Oxidation-Reduction
Reactive Oxygen Species - metabolism
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cited_by cdi_FETCH-LOGICAL-c497t-a3d472c8eb090f4316fa989b2499367007df0d8f1085763c38eb422dee9ce9933
cites cdi_FETCH-LOGICAL-c497t-a3d472c8eb090f4316fa989b2499367007df0d8f1085763c38eb422dee9ce9933
container_end_page 1232
container_issue 8
container_start_page 1229
container_title Metallomics
container_volume 7
creator Atrián-Blasco, E
Cerrada, E
Conte-Daban, A
Testemale, D
Faller, P
Laguna, M
Hureau, C
description Copper(I) coordinating ligands in the Alzheimer's disease context have remained unexplored, despite the biological relevance of this redox state of the copper ion. Here, we show that the PTA ligand can remove copper from Aβ, prevent reactive oxygen species production and oligomer formation, two deleterious events in the disease's etiology.
doi_str_mv 10.1039/c5mt00077g
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subjects Adamantane - analogs & derivatives
Adamantane - pharmacology
Alzheimer Disease - drug therapy
Alzheimer Disease - metabolism
Amyloid beta-Peptides - chemistry
Amyloid beta-Peptides - metabolism
Copper - isolation & purification
Copper - metabolism
Humans
Life Sciences
Organophosphorus Compounds - pharmacology
Oxidation-Reduction
Reactive Oxygen Species - metabolism
title Copper(I) targeting in the Alzheimer's disease context: a first example using the biocompatible PTA ligand
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