Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2-Infected Controllers

Compared with HIV-1, HIV-2 infection is characterized by a larger proportion of slow or nonprogressors. A better understanding of HIV-2 pathogenesis should open new therapeutic avenues to establish control of HIV-1 replication in infected patients. In this study, we studied the production of CD8(+)...

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Published in:The Journal of immunology (1950) 2016-10, Vol.197 (7), p.2787-2795
Main Authors: Angin, Mathieu, Wong, Glenn, Papagno, Laura, Versmisse, Pierre, David, Annie, Bayard, Charles, Charmeteau-De Muylder, Bénédicte, Besseghir, Amel, Thiébaut, Rodolphe, Boufassa, Faroudy, Pancino, Gianfranco, Sauce, Delphine, Lambotte, Olivier, Brun-Vézinet, Françoise, Matheron, Sophie, Rowland-Jones, Sarah L, Cheynier, Rémi, Sáez-Cirión, Asier, Appay, Victor
Format: Article
Language:English
Subjects:
Adult
Aged
CD8-Positive T-Lymphocytes - immunology
Female
HIV Infections - diagnosis
HIV Infections - immunology
HIV Infections - virology
HIV-2 - immunology
Humans
Lentivirus
Life Sciences
Lymphopoiesis - immunology
Male
Middle Aged
Retroviridae
Santé publique et épidémiologie
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Summary:Compared with HIV-1, HIV-2 infection is characterized by a larger proportion of slow or nonprogressors. A better understanding of HIV-2 pathogenesis should open new therapeutic avenues to establish control of HIV-1 replication in infected patients. In this study, we studied the production of CD8(+) T cells and their capacity for viral control in HIV-2 controllers from the French ANRS CO5 HIV-2 cohort. HIV-2 controllers display a robust capacity to support long-term renewal of the CD8(+) T cell compartment by preserving immune resources, including hematopoietic progenitors and thymic activity, which could contribute to the long-term maintenance of the CD8(+) T cell response and the avoidance of premature immune aging. Our data support the presence of HIV-2 Gag-specific CD8(+) T cells that display an early memory differentiation phenotype and robust effector potential in HIV-2 controllers. Accordingly, to our knowledge, we show for the first time that HIV-2 controllers possess CD8(+) T cells that show an unusually strong capacity to suppress HIV-2 infection in autologous CD4(+) T cells ex vivo, an ability that likely depends on the preservation of host immune resources. This effective and durable antiviral response probably participates in a virtuous circle, during which controlled viral replication permits the preservation of potent immune functions, thus preventing HIV-2 disease progression.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.1600693