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Lung cancer screening: Current status and perspective
Abstract Lung cancer screening by low-dose computed tomography (CT) has been proven to reduce lung cancer-related mortality by 20%, in the National Lung cancer Screening Trial (NLST). Low-dose CT acquisition protocols should result in effective dose not exceeding 1.5 mSv, and should be read by radio...
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Published in: | Diagnostic and interventional imaging 2016-10, Vol.97 (10), p.949-953 |
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container_title | Diagnostic and interventional imaging |
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description | Abstract Lung cancer screening by low-dose computed tomography (CT) has been proven to reduce lung cancer-related mortality by 20%, in the National Lung cancer Screening Trial (NLST). Low-dose CT acquisition protocols should result in effective dose not exceeding 1.5 mSv, and should be read by radiologists who have an expertise in the field. A volumetry-based approach similar to that used in the NELSON study allows reducing the rate of positive screens around 2%. The major harm of screening is overdiagnosis, which correspond to the detection of indolent tumours that would not cause the subject death. Ongoing research for the development of useful biomarkers to be combined to imaging could improve the accuracy of lung cancer screening. |
doi_str_mv | 10.1016/j.diii.2016.06.018 |
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subjects | Computed tomography Cone-Beam Computed Tomography - methods Early Detection of Cancer - methods Early Detection of Cancer - trends False Positive Reactions Forecasting Human health and pathology Humans Life Sciences Lung Lung cancer Lung Neoplasms - diagnostic imaging Lung Neoplasms - mortality Lung Neoplasms - prevention & control Pulmonology and respiratory tract Radiation Dosage Radiology Screening Sensitivity and Specificity Tomography, X-Ray Computed - methods |
title | Lung cancer screening: Current status and perspective |
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