Basic Signaling in Cardiac Fibroblasts

Cardiac fibroblasts are commonly known as supporting cells of the cardiac network and exert many essential functions that are fundamental for normal cardiac growth as well as for cardiac remodeling process during pathological conditions. This review focuses on the roles of cardiac fibroblasts in the...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cellular physiology 2017-04, Vol.232 (4), p.725-730
Main Authors: Chacar, Stéphanie, Farès, Nassim, Bois, Patrick, Faivre, Jean‐François
Format: Article
Language:English
Subjects:
Animals
Cell Shape
Fibroblasts - cytology
Fibroblasts - metabolism
Fibrosis
Humans
Life Sciences
Mechanotransduction, Cellular
Myocardium - cytology
Physiology
Signal Transduction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cardiac fibroblasts are commonly known as supporting cells of the cardiac network and exert many essential functions that are fundamental for normal cardiac growth as well as for cardiac remodeling process during pathological conditions. This review focuses on the roles of cardiac fibroblasts in the formation and regulation of the extracellular matrix components, and in maintaining structural, biochemical and mechanical properties of the heart. Additionally, though considered as non‐excitable cells, we review the functional expression in cardiac fibroblasts of a wide variety of transmembrane ion channels which activity may contribute to key regulation of cardiac physiological processes. All together, cardiac fibroblasts which actively participate to fundamental regulation of cardiac physiology and physiopathology processes may represent pertinent targets for pharmacological approaches of cardiac diseases and lead to new tracks of therapeutic strategies. J. Cell. Physiol. 232: 725–730, 2017. © 2016 Wiley Periodicals, Inc. Cardiac fibroblasts are commonly known as supporting cells of the cardiac network and actively participate to fundamental regulation of cardiac physiology and physiopathology. Therefore they represent pertinent targets for pharmacological approaches of cardiac diseases and lead to new tracks of therapeutic strategies.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.25624