High impact of macroaggregated albumin-based tumour dose on response and overall survival in hepatocellular carcinoma patients treated with (90) Y-loaded glass microsphere radioembolization

BACKGROUND & AIMS: Efficacy of radioembolization is derived from radioinduced damage, whereas tumour dosimetry is not considered as yet in prospective clinical trials. OBJECTIVES: This study evaluates the impact of tumour dose (TD), based on (99m) Tc macroaggregated albumin (MAA) quantification,...

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Bibliographic Details
Published in:Liver international 2017-01, Vol.37 (1), p.101-110
Main Authors: Garin, Etienne, Rolland, Yan, Pracht, Marc, Le Sourd, Samuel, Laffont, Sophie, Mesbah, Habiba, Haumont, Laure-Anne, Lenoir, Laurence, Rohou, Tanguy, Brun, Vanessa, Edeline, Julien
Format: Article
Language:English
Subjects:
Cancer
Human health and pathology
Hépatology and Gastroenterology
Life Sciences
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Summary:BACKGROUND & AIMS: Efficacy of radioembolization is derived from radioinduced damage, whereas tumour dosimetry is not considered as yet in prospective clinical trials. OBJECTIVES: This study evaluates the impact of tumour dose (TD), based on (99m) Tc macroaggregated albumin (MAA) quantification, on response and overall survival (OS). MATERIALS AND METHODS: We consecutively included 85 patients with hepatocellular carcinoma treated with (90) Y-loaded glass microspheres. TD was calculated using a quantitative analysis of the MAA SPECT/CT. Responses were assessed after 3 months using the European Association for the Study of the Liver criteria. OS was assessed using Kaplan-Meier tests. RESULTS: Response rate was 80.3% on lesion-based analysis (n=132), and 77.5% on patient-based analysis. The response rate was only 9.1% for patients with TD
ISSN:1478-3223
1478-3231
DOI:10.1111/liv.13220