Inhibition of Cancer Cell Migration by Multiwalled Carbon Nanotubes

Inhibiting cancer cell migration and infiltration to other tissues makes the difference between life and death. Multiwalled carbon nanotubes (MWCNTs) display intrinsic biomimetic properties with microtubules, severely interfering with the function of these protein filaments during cell proliferation...

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Bibliographic Details
Published in:Advanced healthcare materials 2015-08, Vol.4 (11), p.1640-1644
Main Authors: García-Hevia, Lorena, Valiente, Rafael, Fernández-Luna, José L., Flahaut, Emmanuel, Rodríguez-Fernández, Lidia, Villegas, Juan C., González, Jesús, Fanarraga, Mónica L.
Format: Article
Language:English
Subjects:
Biocompatible Materials - chemistry
Biocompatible Materials - toxicity
biomechanics
Biomimetics
Cancer
Cell death
Cell Line, Tumor
Cell Movement - drug effects
Cell Proliferation - drug effects
cytoskeleton
Engineering Sciences
Filaments
Health care
HeLa Cells
Humans
Infiltration
Materials
MCF-7 Cells
metastasis
Microscopy, Confocal
Microtubules
Migration
Multi wall carbon nanotubes
Nanotubes, Carbon - chemistry
Nanotubes, Carbon - toxicity
Neoplasms - metabolism
Neoplasms - pathology
Spectrum Analysis, Raman
tubulin polymers
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Summary:Inhibiting cancer cell migration and infiltration to other tissues makes the difference between life and death. Multiwalled carbon nanotubes (MWCNTs) display intrinsic biomimetic properties with microtubules, severely interfering with the function of these protein filaments during cell proliferation, triggering cell death. Here it is shown MWCNTs disrupt the centrosomal microtubule cytoskeletal organization triggering potent antimigratory effects in different cancer cells.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201500252