N-Cadherin and Fibroblast Growth Factor Receptors crosstalk in the control of developmental and cancer cell migrations

Cell migrations are diverse. They constitutemajor morphogenetic driving forces during embryogenesis, but they contribute also to the loss of tissue homeostasis and cancer growth. Capabilities of cells to migrate as single cells or as collectives are controlled by internal and external signalling, le...

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Bibliographic Details
Published in:European journal of cell biology 2016-11, Vol.95 (11), p.415-426
Main Authors: Nguyen, Thao, Mège, René Marc
Format: Article
Language:English
Subjects:
Animals
Antigens, CD - genetics
Antigens, CD - metabolism
Cadherin
Cadherins - genetics
Cadherins - metabolism
Cancer
Cell invasion
Cell migration
Cell Movement
Cell signalling
Cellular Biology
FGFR
Humans
Life Sciences
Neoplasm Metastasis
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Receptors, Fibroblast Growth Factor - genetics
Receptors, Fibroblast Growth Factor - metabolism
Signal Transduction
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Summary:Cell migrations are diverse. They constitutemajor morphogenetic driving forces during embryogenesis, but they contribute also to the loss of tissue homeostasis and cancer growth. Capabilities of cells to migrate as single cells or as collectives are controlled by internal and external signalling, leading to the reorganisation of their cytoskeleton as well as by the rebalancing of cell-matrix and cell-cell adhesions. Among the genes altered in numerous cancers, cadherins and growth factor receptors are of particular interest for cell migration regulation. In particular, cadherins such as N-cadherin and a class of growth factor receptors, namely FGFRs cooperate to regulate embryonic and cancer cell behaviours. In this review, we discuss on reciprocal crosstalk between N-cadherin and FGFRs during cell migration. Finally, we aim at clarifying the synergy between N-cadherin and FGFR signalling that ensure cellular reorganization during cell movements, mainly during cancer cell migration and metastasis but also during developmental processes.
ISSN:0171-9335
1618-1298
DOI:10.1016/j.ejcb.2016.05.002