H2Me-do2pa: an attractive chelator with fast, stable and inert nat Bi 3+ and 213 Bi 3+ complexation for potential α-radioimmunotherapy applications

The complexation properties of H2Me-do2pa towards nat Bi 3+ reveal a rather fast formation of the [Bi( Me-do2pa )] + complex, which is endowed with a very high thermodynamic stability (log  K BiL = 34.2) and presents a single non-fluxional structure in solution. X-ray diffraction and solution NMR st...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2014-08, Vol.50 (82), p.12371-12374
Main Authors: Lima, Luís M. P., Beyler, Maryline, Oukhatar, Fatima, Le Saec, Patricia, Faivre-Chauvet, Alain, Platas-Iglesias, Carlos, Delgado, Rita, Tripier, Raphaël
Format: Article
Language:English
Subjects:
Chemical Sciences
Coordination chemistry
Organic chemistry
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Summary:The complexation properties of H2Me-do2pa towards nat Bi 3+ reveal a rather fast formation of the [Bi( Me-do2pa )] + complex, which is endowed with a very high thermodynamic stability (log  K BiL = 34.2) and presents a single non-fluxional structure in solution. X-ray diffraction and solution NMR studies showed an octadentate binding of the ligand to the metal ion. The labelling of H2Me-do2pa with 213 Bi was performed and the resulting complex was stable in vitro , sustaining its use as an attractive alternative to H4dota taken here as a reference.
ISSN:1359-7345
1364-548X
DOI:10.1039/C4CC05529B