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H2Me-do2pa: an attractive chelator with fast, stable and inert nat Bi 3+ and 213 Bi 3+ complexation for potential α-radioimmunotherapy applications
The complexation properties of H2Me-do2pa towards nat Bi 3+ reveal a rather fast formation of the [Bi( Me-do2pa )] + complex, which is endowed with a very high thermodynamic stability (log K BiL = 34.2) and presents a single non-fluxional structure in solution. X-ray diffraction and solution NMR st...
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| Published in: | Chemical communications (Cambridge, England) England), 2014-08, Vol.50 (82), p.12371-12374 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c1101-adba679ab97bdcfb9ef820fb5f1a3b4066ad714dd7dc294379b1c104d34eda0f3 |
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| cites | cdi_FETCH-LOGICAL-c1101-adba679ab97bdcfb9ef820fb5f1a3b4066ad714dd7dc294379b1c104d34eda0f3 |
| container_end_page | 12374 |
| container_issue | 82 |
| container_start_page | 12371 |
| container_title | Chemical communications (Cambridge, England) |
| container_volume | 50 |
| creator | Lima, Luís M. P. Beyler, Maryline Oukhatar, Fatima Le Saec, Patricia Faivre-Chauvet, Alain Platas-Iglesias, Carlos Delgado, Rita Tripier, Raphaël |
| description | The complexation properties of
H2Me-do2pa
towards
nat
Bi
3+
reveal a rather fast formation of the [Bi(
Me-do2pa
)]
+
complex, which is endowed with a very high thermodynamic stability (log
K
BiL
= 34.2) and presents a single non-fluxional structure in solution. X-ray diffraction and solution NMR studies showed an octadentate binding of the ligand to the metal ion. The labelling of
H2Me-do2pa
with
213
Bi was performed and the resulting complex was stable
in vitro
, sustaining its use as an attractive alternative to
H4dota
taken here as a reference. |
| doi_str_mv | 10.1039/C4CC05529B |
| format | article |
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H2Me-do2pa
towards
nat
Bi
3+
reveal a rather fast formation of the [Bi(
Me-do2pa
)]
+
complex, which is endowed with a very high thermodynamic stability (log
K
BiL
= 34.2) and presents a single non-fluxional structure in solution. X-ray diffraction and solution NMR studies showed an octadentate binding of the ligand to the metal ion. The labelling of
H2Me-do2pa
with
213
Bi was performed and the resulting complex was stable
in vitro
, sustaining its use as an attractive alternative to
H4dota
taken here as a reference.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/C4CC05529B</identifier><language>eng</language><publisher>Royal Society of Chemistry</publisher><subject>Chemical Sciences ; Coordination chemistry ; Organic chemistry</subject><ispartof>Chemical communications (Cambridge, England), 2014-08, Vol.50 (82), p.12371-12374</ispartof><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1101-adba679ab97bdcfb9ef820fb5f1a3b4066ad714dd7dc294379b1c104d34eda0f3</citedby><cites>FETCH-LOGICAL-c1101-adba679ab97bdcfb9ef820fb5f1a3b4066ad714dd7dc294379b1c104d34eda0f3</cites><orcidid>0000-0002-6540-970X ; 0000-0003-3849-0087 ; 0000-0001-9364-788X ; 0000-0002-6380-6306 ; 0000-0002-6989-9654</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://hal.univ-brest.fr/hal-01517757$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Lima, Luís M. P.</creatorcontrib><creatorcontrib>Beyler, Maryline</creatorcontrib><creatorcontrib>Oukhatar, Fatima</creatorcontrib><creatorcontrib>Le Saec, Patricia</creatorcontrib><creatorcontrib>Faivre-Chauvet, Alain</creatorcontrib><creatorcontrib>Platas-Iglesias, Carlos</creatorcontrib><creatorcontrib>Delgado, Rita</creatorcontrib><creatorcontrib>Tripier, Raphaël</creatorcontrib><title>H2Me-do2pa: an attractive chelator with fast, stable and inert nat Bi 3+ and 213 Bi 3+ complexation for potential α-radioimmunotherapy applications</title><title>Chemical communications (Cambridge, England)</title><description>The complexation properties of
H2Me-do2pa
towards
nat
Bi
3+
reveal a rather fast formation of the [Bi(
Me-do2pa
)]
+
complex, which is endowed with a very high thermodynamic stability (log
K
BiL
= 34.2) and presents a single non-fluxional structure in solution. X-ray diffraction and solution NMR studies showed an octadentate binding of the ligand to the metal ion. The labelling of
H2Me-do2pa
with
213
Bi was performed and the resulting complex was stable
in vitro
, sustaining its use as an attractive alternative to
H4dota
taken here as a reference.</description><subject>Chemical Sciences</subject><subject>Coordination chemistry</subject><subject>Organic chemistry</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNpFkE1OwzAQhSMEEqWw4QTe8hOwYyeu2bURUKQiNiCxiyb-UYySOHJMoffgIlyEM5H-CGYz856-eYsXRacEXxFMxXXO8hynaSJme9GI0IzFKZu87q_vVMScsvQwOur7NzwMSSej6GuePOpYuaSDGwQtghA8yGCXGslK1xCcRx82VMhAHy5RH6Cs9QAqZFvtA2ohoJlF9GLjJYTulHRNV-tPCNa1yAwhnQu6DRZq9PMde1DW2aZ5b12otIduhaDrais3fH8cHRioe32y2-Po5e72OZ_Hi6f7h3y6iCUhmMSgSsi4gFLwUklTCm0mCTZlagjQkuEsA8UJU4ormQhGuSiJJJgpyrQCbOg4OtvmVlAXnbcN-FXhwBbz6aJYe0NHhPOUL8nAnm9Z6V3fe23-Hggu1t0X_93TX6wCd_w</recordid><startdate>20140825</startdate><enddate>20140825</enddate><creator>Lima, Luís M. P.</creator><creator>Beyler, Maryline</creator><creator>Oukhatar, Fatima</creator><creator>Le Saec, Patricia</creator><creator>Faivre-Chauvet, Alain</creator><creator>Platas-Iglesias, Carlos</creator><creator>Delgado, Rita</creator><creator>Tripier, Raphaël</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-6540-970X</orcidid><orcidid>https://orcid.org/0000-0003-3849-0087</orcidid><orcidid>https://orcid.org/0000-0001-9364-788X</orcidid><orcidid>https://orcid.org/0000-0002-6380-6306</orcidid><orcidid>https://orcid.org/0000-0002-6989-9654</orcidid></search><sort><creationdate>20140825</creationdate><title>H2Me-do2pa: an attractive chelator with fast, stable and inert nat Bi 3+ and 213 Bi 3+ complexation for potential α-radioimmunotherapy applications</title><author>Lima, Luís M. P. ; Beyler, Maryline ; Oukhatar, Fatima ; Le Saec, Patricia ; Faivre-Chauvet, Alain ; Platas-Iglesias, Carlos ; Delgado, Rita ; Tripier, Raphaël</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1101-adba679ab97bdcfb9ef820fb5f1a3b4066ad714dd7dc294379b1c104d34eda0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Chemical Sciences</topic><topic>Coordination chemistry</topic><topic>Organic chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lima, Luís M. P.</creatorcontrib><creatorcontrib>Beyler, Maryline</creatorcontrib><creatorcontrib>Oukhatar, Fatima</creatorcontrib><creatorcontrib>Le Saec, Patricia</creatorcontrib><creatorcontrib>Faivre-Chauvet, Alain</creatorcontrib><creatorcontrib>Platas-Iglesias, Carlos</creatorcontrib><creatorcontrib>Delgado, Rita</creatorcontrib><creatorcontrib>Tripier, Raphaël</creatorcontrib><collection>CrossRef</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lima, Luís M. P.</au><au>Beyler, Maryline</au><au>Oukhatar, Fatima</au><au>Le Saec, Patricia</au><au>Faivre-Chauvet, Alain</au><au>Platas-Iglesias, Carlos</au><au>Delgado, Rita</au><au>Tripier, Raphaël</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>H2Me-do2pa: an attractive chelator with fast, stable and inert nat Bi 3+ and 213 Bi 3+ complexation for potential α-radioimmunotherapy applications</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><date>2014-08-25</date><risdate>2014</risdate><volume>50</volume><issue>82</issue><spage>12371</spage><epage>12374</epage><pages>12371-12374</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>The complexation properties of
H2Me-do2pa
towards
nat
Bi
3+
reveal a rather fast formation of the [Bi(
Me-do2pa
)]
+
complex, which is endowed with a very high thermodynamic stability (log
K
BiL
= 34.2) and presents a single non-fluxional structure in solution. X-ray diffraction and solution NMR studies showed an octadentate binding of the ligand to the metal ion. The labelling of
H2Me-do2pa
with
213
Bi was performed and the resulting complex was stable
in vitro
, sustaining its use as an attractive alternative to
H4dota
taken here as a reference.</abstract><pub>Royal Society of Chemistry</pub><doi>10.1039/C4CC05529B</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-6540-970X</orcidid><orcidid>https://orcid.org/0000-0003-3849-0087</orcidid><orcidid>https://orcid.org/0000-0001-9364-788X</orcidid><orcidid>https://orcid.org/0000-0002-6380-6306</orcidid><orcidid>https://orcid.org/0000-0002-6989-9654</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2014-08, Vol.50 (82), p.12371-12374 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_01517757v1 |
| source | Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list) |
| subjects | Chemical Sciences Coordination chemistry Organic chemistry |
| title | H2Me-do2pa: an attractive chelator with fast, stable and inert nat Bi 3+ and 213 Bi 3+ complexation for potential α-radioimmunotherapy applications |
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