Dynamical response of nanomechanical oscillators in immiscible viscous fluid for in vitro biomolecular recognition

Dynamical response of nanomechanical cantilever structures immersed in a viscous fluid is important to in vitro single-molecule force spectroscopy, biomolecular recognition of disease-specific proteins, and the study of microscopic protein dynamics. Here we study the stochastic response of biofuncti...

Full description

Saved in:
Bibliographic Details
Published in:Physical review letters 2006-05, Vol.96 (18), p.186105-186105, Article 186105
Main Authors: Dorignac, Jerome, Kalinowski, Agnieszka, Erramilli, Shyamsunder, Mohanty, Pritiraj
Format: Article
Language:English
Subjects:
Biological Physics
Physics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Dynamical response of nanomechanical cantilever structures immersed in a viscous fluid is important to in vitro single-molecule force spectroscopy, biomolecular recognition of disease-specific proteins, and the study of microscopic protein dynamics. Here we study the stochastic response of biofunctionalized nanomechanical cantilever beams in a viscous fluid. Using the fluctuation-dissipation theorem we derive an exact expression for the spectral density of displacement and a linear approximation for resonance frequency shift. We find that in a viscous solution the frequency shift of the nanoscale cantilever is determined by surface stress generated by biomolecular interaction with negligible contributions from mass loading due to the biomolecules.
ISSN:0031-9007
1079-7114
DOI:10.1103/PhysRevLett.96.186105