A review of mixing and propulsion of chyme in the small intestine: fresh insights from new methods

• Published in: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology Biochemical, systemic, and environmental physiology, 2015-05, Vol.185 (4), p.369-387
• Main Authors: Lentle, R. G., de Loubens, C.
• Format: Article
• Language: English
• Subjects: Animal Physiology; Biochemistry; Biomedical and Life Sciences; Biomedicine; Deformation; Digestion - physiology; Gastrointestinal Contents - chemistry; Human Physiology; Humans; Intestine, Small - metabolism; Life Sciences; Peristalsis - physiology; Review; Rheology; Rheology - methods; Small intestine; Smooth muscle; Spatio-Temporal Analysis; Viscosity; Vortices; Zoology
• ISSN: 0174-1578; 1432-136X
• DOI: 10.1007/s00360-015-0889-5

The small intestine is a convoluted flexible tube of inconstant form and capacity through which chyme is propelled and mixed by varying patterns of contraction. These inconstancies have prevented quantitative comparisons of the manner in which contractile activity engenders mixing of contained chyme. Recent quantitative work based on spatiotemporal mapping of intestinal contractions, macro- and micro-rheology, particle image velocimetry and real-time modelling has provided new insights into this process. Evidence indicates that the speeds and patterns of the various types of small intestinal contraction are insufficient to secure optimal mixing and enzymatic digestion over a minimal length of intestine. Hence particulate substrates and soluble nutrients become dispersed along the length of the lumen. Mixing within the lumen is not turbulent but results from localised folding and kneading of the contents by contractions but is augmented by the inconstant spatial disposition of the contractions and their component contractile processes. The latter include inconstancies in the sites of commencement and the directions of propagation of contraction in component groups of smooth muscle cells and in the coordination of the radial and circular components of smooth muscle contraction. Evidence suggests there is ongoing augmentation of mixing at the periphery of the lumen, during both the post-prandial and inter-meal periods, to promote flow around and between adjacent villi. This results largely from folding of the relatively inelastic mucosa during repeated radial and longitudinal muscular contraction, causing chyme to be displaced by periodic crowding and separation of the tips of the relatively rigid villi. Further, micro-rheological studies indicate that such peripheral mixing may extend to the apices of enterocytes owing to discontinuities in the mobile mucus layer that covers the ileal mucosa.