Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions

The commercial availability of combined magnetic resonance imaging (MRI)/positron emission tomography (PET) scanners for clinical use has increased demand for easily prepared agents which offer signal or contrast in both modalities. Herein we describe a new class of silica coated iron-oxide nanorods...

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Bibliographic Details
Published in:Nanoscale 2015-09, Vol.7 (36), p.14889-14896
Main Authors: Burke, Benjamin P, Baghdadi, Neazar, Kownacka, Alicja E, Nigam, Shubhanchi, Clemente, Gonçalo S, Al-Yassiry, Mustafa M, Domarkas, Juozas, Lorch, Mark, Pickles, Martin, Gibbs, Peter, Tripier, Raphaël, Cawthorne, Christopher, Archibald, Stephen J
Format: Article
Language:English
Subjects:
Animals
Chelating
Chemical Sciences
Coating
Female
Ferric Compounds - chemistry
Ferric Compounds - pharmacology
Gallium Radioisotopes - chemistry
Gallium Radioisotopes - pharmacology
Heterocyclic Compounds, 1-Ring - chemistry
Heterocyclic Compounds, 1-Ring - pharmacology
Imaging
Isotope Labeling - methods
Magnetic resonance imaging
Mice
Mice, Nude
Nanorods
Nanotubes - chemistry
Polyethylene Glycols - chemistry
Polyethylene Glycols - pharmacology
Positron emission
Positron-Emission Tomography - methods
Radiolabelling
Silicon dioxide
Silicon Dioxide - chemistry
Silicon Dioxide - pharmacology
Tomography
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Summary:The commercial availability of combined magnetic resonance imaging (MRI)/positron emission tomography (PET) scanners for clinical use has increased demand for easily prepared agents which offer signal or contrast in both modalities. Herein we describe a new class of silica coated iron-oxide nanorods (NRs) coated with polyethylene glycol (PEG) and/or a tetraazamacrocyclic chelator (DO3A). Studies of the coated NRs validate their composition and confirm their properties as in vivo T2 MRI contrast agents. Radiolabelling studies with the positron emitting radioisotope gallium-68 (t1/2 = 68 min) demonstrate that, in the presence of the silica coating, the macrocyclic chelator was not required for preparation of highly stable radiometal-NR constructs. In vivo PET-CT and MR imaging studies show the expected high liver uptake of gallium-68 radiolabelled nanorods with no significant release of gallium-68 metal ions, validating our innovation to provide a novel simple method for labelling of iron oxide NRs with a radiometal in the absence of a chelating unit that can be used for high sensitivity liver imaging.
ISSN:2040-3364
2040-3372
DOI:10.1039/c5nr02753e