A tandem mass spectrometry-based method to assess the architectural purity of synthetic polymers: a case of a cyclic polylactide obtained by click chemistry

A tandem mass spectrometry-based method is developed to determine the degree of purity achieved in the cyclization of a linear poly( l -lactide) prepared by copper-catalyzed alkyne-azide cycloaddition. When proton nuclear magnetic resonance, size-exclusion chromatography, and single-stage mass spect...

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Bibliographic Details
Published in:Polymer chemistry 2015-01, Vol.6 (1), p.64-69
Main Authors: Josse, Thomas, De Winter, Julien, Dubois, Philippe, Coulembier, Olivier, Gerbaux, Pascal, Memboeuf, Antony
Format: Article
Language:English
Subjects:
Alkynes
Chemical Sciences
Chromatography
Mass spectrometry
Polylactides
Polymer chemistry
Polymers
Purity
Spectroscopy
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Summary:A tandem mass spectrometry-based method is developed to determine the degree of purity achieved in the cyclization of a linear poly( l -lactide) prepared by copper-catalyzed alkyne-azide cycloaddition. When proton nuclear magnetic resonance, size-exclusion chromatography, and single-stage mass spectrometry are unable to demonstrate the presence of a residual linear polymer, the proposed ESI-tandem mass spectrometry methodology allows detection of starting material traces (
ISSN:1759-9954
1759-9962
DOI:10.1039/C4PY01087F