Simple and Specific Grafting of Antibacterial Peptides on Silicone Catheters

To fight against nosocomial infection initiated by colonization of medical devices, a strategy enabling the direct and fast functionalization of silicone surfaces is proposed. This strategy proceeds in a site‐specific way using original hybrid silylated antibacterial peptides. This safe and up‐scala...

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Bibliographic Details
Published in:Advanced healthcare materials 2016-12, Vol.5 (23), p.3067-3073
Main Authors: Pinese, Coline, Jebors, Said, Echalier, Cécile, Licznar-Fajardo, Patricia, Garric, Xavier, Humblot, Vincent, Calers, Christophe, Martinez, Jean, Mehdi, Ahmad, Subra, Gilles
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
antibacterial silicone
Antiinfectives and antibacterials
Bacterial Adhesion - drug effects
Biocompatibility
Biofilms - drug effects
Catheters
Chemical Sciences
Coated Materials, Biocompatible - chemistry
Coated Materials, Biocompatible - pharmacology
Coatings
Cross Infection - drug therapy
hybrid materials
Microbial Sensitivity Tests - methods
Peptides
Peptides - chemistry
Peptides - pharmacology
Polymers - chemistry
Robustness
Silicones
Silicones - chemistry
Silver - chemistry
silylated peptides
Strategy
surface modification
Surface Properties - drug effects
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Summary:To fight against nosocomial infection initiated by colonization of medical devices, a strategy enabling the direct and fast functionalization of silicone surfaces is proposed. This strategy proceeds in a site‐specific way using original hybrid silylated antibacterial peptides. This safe and up‐scalable method guarantees a covalent and robust immobilization with the correct orientation of the bioactive moiety. Importantly it also avoids multi‐step chemical modifications of the surface or multi‐layer polymer coatings. As proof of concept, antibacterial silicone catheter has been prepared whose immediate and long term efficiency is superior by comparison to similar silver‐embedded materials. A strategy enabling the direct and fast functionalization of silicone surfaces with antibacterial peptides is developed. Thanks to hybrid silylated bioactive molecules, no multi step surface modifications or polymer coating are required. Antibacterial silicone catheters are obtained and proved to be more efficient than commercially available silver‐embedded devices.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201600757