Bringing Prebiotic Nucleosides and Nucleotides Down to Earth

There may be more than one way leading to RNA: Recent discoveries in the synthesis of nucleoside and nucleotide precursors are described and put into the wider context of prebiotic systems chemistry. Mixing Butlerow's carbohydrate precursors with Traube's 5‐formylaminopyrimidines has led t...

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Bibliographic Details
Published in:Angewandte Chemie 2016-11, Vol.55 (45), p.13930-13933
Main Authors: Fiore, Michele, Strazewski, Peter
Format: Article
Language:English
Subjects:
barbituric acid
Biochemistry
Biochemistry, Molecular Biology
Chemical Sciences
Earth
formamides
formamidopyrimidines
Life Sciences
melamine
Nucleic Acid Conformation
Nucleosides - chemistry
Nucleotides - chemistry
Organic chemistry
prebiotic systems chemistry
Prebiotics
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Summary:There may be more than one way leading to RNA: Recent discoveries in the synthesis of nucleoside and nucleotide precursors are described and put into the wider context of prebiotic systems chemistry. Mixing Butlerow's carbohydrate precursors with Traube's 5‐formylaminopyrimidines has led to the formation of prebiotic purine nucleosides whereas the mixing of 5‐phosphoribose with barbituric acid and melamine gave supramolecular fibers from stacks of Whitesides’ rosettas.
ISSN:1433-7851
0044-8249
1521-3773
1521-3757
DOI:10.1002/anie.201606232