Longitudinal imaging in biological tissues with a single laser shot correlation system

We demonstrate the potential of a new optical imaging system to directly obtain a longitudinal slice of a biological sample. The system, based on a single-shot optical correlator, operates a time-to-space conversion and an optical time-gating by sum-frequency generation in a nonlinear crystal. Owing...

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Bibliographic Details
Published in:Optics express 2002-01, Vol.10 (1), p.35-40
Main Authors: Bordenave, E, Abraham, Emmanuel, Jonusauskas, G, Oberle, J, Rulliere, Claude
Format: Article
Language:English
Subjects:
Optics
Physics
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Summary:We demonstrate the potential of a new optical imaging system to directly obtain a longitudinal slice of a biological sample. The system, based on a single-shot optical correlator, operates a time-to-space conversion and an optical time-gating by sum-frequency generation in a nonlinear crystal. Owing to the high speed acquisition of the technique, internal structures of in-vivo tissues can be imaged at video rate.With this apparatus, we recorded longitudinal images of ex vivo mouse ear and in vivo human skin with a depth resolution of approximately 15 microm.
ISSN:1094-4087
1094-4087
DOI:10.1364/OE.10.000035