Roles of adaptor proteins in regulation of bacterial proteolysis

Highlights ► Regulated degradation by ATP-dependent proteases frequently depends upon delivery of the substrate by adaptors. ► Regulation of activity of adaptors by anti-adaptors allows environmental modulation of protein turnover. ► Structural studies are uncovering how adaptors bind and hand over...

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Bibliographic Details
Published in:Current opinion in microbiology 2013-04, Vol.16 (2), p.140-147
Main Authors: Battesti, Aurelia, Gottesman, Susan
Format: Article
Language:English
Subjects:
Bacteria
Bacteria - enzymology
Bacteria - metabolism
Bacterial Proteins - metabolism
Bacteriology
Biochemistry
Biochemistry, Molecular Biology
cell growth
eukaryotic cells
Life Sciences
Microbiology and Parasitology
Molecular biology
Pathology
Peptide Hydrolases - metabolism
proteasome endopeptidase complex
proteinases
proteins
Proteolysis
quality control
Substrate Specificity
Virology
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Summary:Highlights ► Regulated degradation by ATP-dependent proteases frequently depends upon delivery of the substrate by adaptors. ► Regulation of activity of adaptors by anti-adaptors allows environmental modulation of protein turnover. ► Structural studies are uncovering how adaptors bind and hand over the substrate to the protease.
ISSN:1369-5274
1879-0364
1369-5274
DOI:10.1016/j.mib.2013.01.002