Fatal Neisseria macacae infective endocarditis: first report

• Published in: Infection 2017-06, Vol.45 (3), p.369-371
• Main Authors: Vecten, Maude, Martel, Hélène, Casalta, Jean-Paul, Hubert, Sandrine, Lepidi, Hubert, Habib, Gilbert, Raoult, Didier, Gouriet, Frédérique
• Format: Article
• Language: English
• Subjects: Abscess - diagnosis; Abscess - drug therapy; Abscess - microbiology; Abscesses; Aged; Anti-Bacterial Agents - therapeutic use; Antibiotics; Aortic valve; Aortic Valve - microbiology; Blood culture; Case Report; Case reports; Ceftriaxone - therapeutic use; Endocarditis; Endocarditis, Bacterial - diagnosis; Endocarditis, Bacterial - drug therapy; Endocarditis, Bacterial - microbiology; Family Medicine; Fatal Outcome; Fatalities; France; General Practice; Gentamicins - therapeutic use; Gram-Negative Bacterial Infections - diagnosis; Gram-Negative Bacterial Infections - drug therapy; Gram-Negative Bacterial Infections - microbiology; Heart; Heart diseases; Hemorrhage; Human health and pathology; Humans; Infectious Diseases; Internal Medicine; Life Sciences; Male; Medicine; Medicine & Public Health; Monkeys; Neisseria - isolation & purification; Neisseria - physiology; Oropharynx; Repair; RNA, Bacterial - analysis; RNA, Ribosomal, 16S - analysis; rRNA 16S; Stroke; Surgery; Therapy
• ISSN: 0300-8126; 1439-0973
• DOI: 10.1007/s15010-017-0985-4

Introduction Neisseria macacae is a Gram-negative diplococcus, found in the oropharynx of healthy Rhesus Monkeys. Infections caused by N. macacae in humans are extremely rare. Case presentation We present here the first case of N. macacae infective endocarditis in a 65-year-old man with a native aortic valve infection complicated by a peri-aortic abscess . N. macacae was isolated from blood culture and was found on the cardiac valve using 16S rDNA detection. Despite an appropriate antibiotic therapy, and aortic homograft replacement, and mitral repair, the patient died 4 days after surgery from a massive hemorrhagic stroke.