Cerebrospinal fluid volume does not have etiological role in the incidence of positional skull deformities

• Published in: Journal of cranio-maxillo-facial surgery 2017-09, Vol.45 (9), p.1387-1393
• Main Authors: Captier, Guillaume, MD, PhD, Galeron, Adrien, MSc, Subsol, Gérard, PhD, Solinhac, Melissa, MSc, Roujeau, Thomas, MD, Leboucq, Nicolas, MD, Herlin, Christian, MD, PhD
• Format: Article
• Language: English
• Subjects: 3D imaging; Brachycephaly; Brain; Brain - anatomy & histology; Brain - diagnostic imaging; Case-Control Studies; Cerebral Ventricles - anatomy & histology; Cerebral Ventricles - diagnostic imaging; Cerebrospinal Fluid; Computer Science; Dentistry; Female; Graphics; Humans; Imaging, Three-Dimensional; Infant; Male; Non-synostotic plagiocephaly; Organ Size; Plagiocephaly, Nonsynostotic - diagnostic imaging; Plagiocephaly, Nonsynostotic - etiology; Retrospective Studies; Segmentation; Surgery; Tomography, X-Ray Computed
• ISSN: 1010-5182; 1878-4119
• DOI: 10.1016/j.jcms.2017.06.005

Abstract Background Positional skull deformities (PSD) are becoming a daily health concern for craniofacial surgeons. Several reports have indicated that cerebrospinal fluid (CSF) space increases on computed tomography (CT) scans of infants suffering from PSD, suggesting a potential causal link. Here, we describe a semi-automatic method to estimate total brain and CSF volumes quantitatively. We tested the potential correlation between total CSF volume and the occurrence of PSD. Methods A single-center retrospective study was carried out using 79 CT scans of PSD and 60 CT scans of control subjects. The endocranium was segmented automatically using a three-dimensional deformable surface model, and the brain was segmented using a semi-automatic threshold-based method. Total CSF volume was estimated based on the difference between endocranial and brain volumes. Results Automatic segmentation of the endocranium was possible in 75 CT scans. Semi-automatic brain and CSF volume evaluations were performed in 40 CT scans of infants with PSD (18 = occipital plagiocephaly, 11 = fronto-occipital plagiocephaly, and 11 = posterior brachycephaly) and in six control CT scans. Endocranial and total CSF volumes were not significantly different between patients with PSD and controls. The occipital plagiocephaly group had an enlarged brain volume compared with that in patients in the other groups. Conclusions Total CSF volume did not change in infants with PSD, and the results do not support a role for volume changes in CSF in the etiology of PSD. Macrocephaly in patients with occipital plagiocephaly may be a specific etiological factor compared with that in other PSDs.