Myocardial Infarction–Associated Transcript, a Long Noncoding RNA, Is Overexpressed During Dilated Cardiomyopathy Due to Chronic Chagas Disease

Long noncoding RNAs (lncRNAs) modulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels. Dysregulation of the lncRNA known as myocardial infarction–associated transcript (MIAT) has been associated with myocardial infarction. Chagas disease causes a severe inflammato...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 2016-07, Vol.214 (1), p.161-165
Main Authors: Frade, Amanda Farage, Laugier, Laurie, Ferreira, Ludmila Rodrigues Pinto, Baron, Monique Andrade, Benvenuti, Luiz Alberto, Teixeira, Priscila Camillo, Navarro, Isabela Cunha, Cabantous, Sandrine, Ferreira, Frederico Moraes, da Silva Cândido, Darlan, Gaiotto, Fabio Antônio, Bacal, Fernando, Pomerantzeff, Pablo, Santos, Ronaldo Honorato Barros, Kalil, Jorge, Cunha-Neto, Edecio, Chevillard, Christophe
Format: Article
Language:English
Subjects:
Animals
Chagas Disease - complications
Chagas Disease - genetics
Chagas Disease - physiopathology
Female
Gene Expression Profiling
Humans
Life Sciences
Male
Mice
Microbiology and Parasitology
Myocardial Infarction - etiology
Myocardial Infarction - genetics
PATHOGENESIS AND HOST RESPONSE
RNA, Long Noncoding
Transcription Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Long noncoding RNAs (lncRNAs) modulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels. Dysregulation of the lncRNA known as myocardial infarction–associated transcript (MIAT) has been associated with myocardial infarction. Chagas disease causes a severe inflammatory dilated chronic cardiomyopathy (CCC). We investigated the role of MIAT in CCC. A whole-transcriptome analysis of heart biopsy specimens and formalin-fixed, paraffin-embedded samples revealed that MIAT was overexpressed in patients with CCC, compared with subjects with noninflammatory dilated cardiomyopathy and controls. These results were confirmed in a mouse model. Results suggest that MIAT is a specific biomarker of CCC.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiw095