The role of the capping bond effect on pyclen Y-nat(3+)/Y-90(3+) chelates: full control of the regiospecific N-functionalization makes the difference

Thanks to a smart regiospecific N-functionalization, a pyclen based ligand bearing one picolinate and two acetate arms organized in a dissymmetric manner was synthesized for Y3+ complexation, and compared to its symmetric analogue. The nature of the capping bonds around the metal coordination enviro...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2017-09, Vol.53 (69), p.9534-9537
Main Authors: Le Fur, Mariane, Beyler, Maryline, Molnar, Eniko, Fougere, Olivier, Esteban-Gomez, David, Tircso, Gyula, Platas-Iglesias, Carlos, Lepareur, Nicolas, Rousseaux, Olivier, Tripier, Raphaël
Format: Article
Language:English
Subjects:
Cancer
Endocrinology and metabolism
Food and Nutrition
Human health and pathology
Life Sciences
Online Access:Get full text
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Summary:Thanks to a smart regiospecific N-functionalization, a pyclen based ligand bearing one picolinate and two acetate arms organized in a dissymmetric manner was synthesized for Y3+ complexation, and compared to its symmetric analogue. The nature of the capping bonds around the metal coordination environment has a dramatic effect on the properties of the chelate, the Y-nat(3+) and Y-90(3+) dissymmetric derivatives presenting enhanced thermodynamic stability and kinetic inertness.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc05088g