Electron paramagnetic resonance of radicals induced in drugs and excipients by radiation or mechanical treatments

Radiation as well as mechanical treatments induced in drugs and excipients radicals, which can be studied by electron paramagnetic resonance. A special attention is pointed about the use of electron paramagnetic resonance (EPR) to bring the proof whether or not a drug has been irradiated or not. We...

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Bibliographic Details
Published in:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Molecular and biomolecular spectroscopy, 2002-04, Vol.58 (6), p.1313-1320
Main Authors: Raffi, J., Gelly, S., Barral, L., Burger, F., Piccerelle, P., Prinderre, P., Baron, M., Chamayou, A.
Format: Article
Language:English
Subjects:
Amino Acids
Ampicillin - pharmacology
Anti-Bacterial Agents - pharmacology
Chromatographic analysis
Chromatography, Gas
Drug
Drug therapy
Electron paramagnetic resonance
Electron Spin Resonance Spectroscopy - methods
Engineering Sciences
Free Radicals
Gamma Rays
Hot Temperature
Irradiation
Mechanical treatment
Olive Oil
Plant Oils - pharmacology
Radiation
Radiotherapy
Temperature
Thermoluminescence
Ultraviolet Rays
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Summary:Radiation as well as mechanical treatments induced in drugs and excipients radicals, which can be studied by electron paramagnetic resonance. A special attention is pointed about the use of electron paramagnetic resonance (EPR) to bring the proof whether or not a drug has been irradiated or not. We also discuss of other methods (thermoluminescence (TL), gas phase chromatography (GPC)) which can be used to bring the same proof in case of irradiated drugs, excipients and cosmetic products.
ISSN:1386-1425
1873-3557
DOI:10.1016/S1386-1425(01)00720-X