Near-infrared optical guided surgery of highly infiltrative fibrosarcomas in cats using an anti-αvß3 integrin molecular probe

We investigated how near-infrared imaging could improve highly infiltrative spontaneous fibrosarcoma surgery in 12 cats in a clinical veterinary phase. We used an RGD-based nanoprobe at different doses and times before surgery and a portable clinical grade imaging system. All tumours were labelled b...

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Bibliographic Details
Published in:Cancer letters 2013-07, Vol.334 (2), p.188-195
Main Authors: Wenk, Christiane H.F., Ponce, Frédérique, Guillermet, Stéphanie, Tenaud, Corinne, Boturyn, Didier, Dumy, Pascal, Watrelot-Virieux, Dorothée, Carozzo, Claude, Josserand, Véronique, Coll, Jean-Luc
Format: Article
Language:English
Subjects:
Animals
Cat Diseases - metabolism
Cat Diseases - surgery
Cats
Chemical Sciences
Female
Fibrosarcoma
Fibrosarcoma - metabolism
Fibrosarcoma - radiotherapy
Fibrosarcoma - surgery
Fibrosarcoma - veterinary
fluorescence
Fluorescence imaging
Fluorescent Antibody Technique - methods
Fluorescent Antibody Technique - veterinary
image analysis
Image Enhancement - methods
Integrin alphaVbeta3 - analysis
Integrin alphaVbeta3 - metabolism
integrins
Male
Molecular Probes
Oncology
RGD
Spectroscopy, Near-Infrared - methods
Spectroscopy, Near-Infrared - veterinary
Surgery
Tissue Distribution
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Summary:We investigated how near-infrared imaging could improve highly infiltrative spontaneous fibrosarcoma surgery in 12 cats in a clinical veterinary phase. We used an RGD-based nanoprobe at different doses and times before surgery and a portable clinical grade imaging system. All tumours were labelled by the tracer and had an overall tumour-to-healthy tissue ratio of 14±1 during surgery. No false negatives were found, and the percentage of tumour cells was linearly correlated with the fluorescence intensity. All cats recovered well and were submitted to long-term follow-up that is currently on-going 1year after the beginning of the study.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2012.10.041