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Near-infrared optical guided surgery of highly infiltrative fibrosarcomas in cats using an anti-αvß3 integrin molecular probe

We investigated how near-infrared imaging could improve highly infiltrative spontaneous fibrosarcoma surgery in 12 cats in a clinical veterinary phase. We used an RGD-based nanoprobe at different doses and times before surgery and a portable clinical grade imaging system. All tumours were labelled b...

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Published in:	Cancer letters 2013-07, Vol.334 (2), p.188-195
Main Authors:	Wenk, Christiane H.F., Ponce, Frédérique, Guillermet, Stéphanie, Tenaud, Corinne, Boturyn, Didier, Dumy, Pascal, Watrelot-Virieux, Dorothée, Carozzo, Claude, Josserand, Véronique, Coll, Jean-Luc
Format:	Article
Language:	English
Subjects:	Animals Cat Diseases - metabolism Cat Diseases - surgery Cats Chemical Sciences Female Fibrosarcoma Fibrosarcoma - metabolism Fibrosarcoma - radiotherapy Fibrosarcoma - surgery Fibrosarcoma - veterinary fluorescence Fluorescence imaging Fluorescent Antibody Technique - methods Fluorescent Antibody Technique - veterinary image analysis Image Enhancement - methods Integrin alphaVbeta3 - analysis Integrin alphaVbeta3 - metabolism integrins Male Molecular Probes Oncology RGD Spectroscopy, Near-Infrared - methods Spectroscopy, Near-Infrared - veterinary Surgery Tissue Distribution
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creator	Wenk, Christiane H.F. Ponce, Frédérique Guillermet, Stéphanie Tenaud, Corinne Boturyn, Didier Dumy, Pascal Watrelot-Virieux, Dorothée Carozzo, Claude Josserand, Véronique Coll, Jean-Luc
description	We investigated how near-infrared imaging could improve highly infiltrative spontaneous fibrosarcoma surgery in 12 cats in a clinical veterinary phase. We used an RGD-based nanoprobe at different doses and times before surgery and a portable clinical grade imaging system. All tumours were labelled by the tracer and had an overall tumour-to-healthy tissue ratio of 14±1 during surgery. No false negatives were found, and the percentage of tumour cells was linearly correlated with the fluorescence intensity. All cats recovered well and were submitted to long-term follow-up that is currently on-going 1year after the beginning of the study.
doi_str_mv	10.1016/j.canlet.2012.10.041
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We used an RGD-based nanoprobe at different doses and times before surgery and a portable clinical grade imaging system. All tumours were labelled by the tracer and had an overall tumour-to-healthy tissue ratio of 14±1 during surgery. No false negatives were found, and the percentage of tumour cells was linearly correlated with the fluorescence intensity. 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We used an RGD-based nanoprobe at different doses and times before surgery and a portable clinical grade imaging system. All tumours were labelled by the tracer and had an overall tumour-to-healthy tissue ratio of 14±1 during surgery. No false negatives were found, and the percentage of tumour cells was linearly correlated with the fluorescence intensity. All cats recovered well and were submitted to long-term follow-up that is currently on-going 1year after the beginning of the study.</description><subject>Animals</subject><subject>Cat Diseases - metabolism</subject><subject>Cat Diseases - surgery</subject><subject>Cats</subject><subject>Chemical Sciences</subject><subject>Female</subject><subject>Fibrosarcoma</subject><subject>Fibrosarcoma - metabolism</subject><subject>Fibrosarcoma - radiotherapy</subject><subject>Fibrosarcoma - surgery</subject><subject>Fibrosarcoma - veterinary</subject><subject>fluorescence</subject><subject>Fluorescence imaging</subject><subject>Fluorescent Antibody Technique - methods</subject><subject>Fluorescent Antibody Technique - veterinary</subject><subject>image analysis</subject><subject>Image Enhancement - methods</subject><subject>Integrin alphaVbeta3 - analysis</subject><subject>Integrin alphaVbeta3 - metabolism</subject><subject>integrins</subject><subject>Male</subject><subject>Molecular Probes</subject><subject>Oncology</subject><subject>RGD</subject><subject>Spectroscopy, Near-Infrared - methods</subject><subject>Spectroscopy, Near-Infrared - veterinary</subject><subject>Surgery</subject><subject>Tissue Distribution</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9kU2O1DAQhS0EYpqBGyDwclikseM4cTZIoxEwSC1YwKytilNJu-Ukje201CuOwhk4A3vOhKMMs0SyZLnqqx-_R8hLzrac8fLtYWtgdBi3OeN5Cm1ZwR-RDVdVnlW1Yo_JhglWZEIJeUGehXBgjMmikk_JRS5yxspKbsiPzwg-s2PnwWNLp2O0BhztZ9umZ5h9j_5Mp47ubb93Z5pI66KHaE9IO9v4KYA30wAhpaiBGOgc7NhTGNOJNvvz6_T7p0jJiL1PyDA5NLMDT49-avA5edKBC_ji_r4kdx_ef7u5zXZfPn66ud5lRggZs7op21w2jUQUTEJuFJj0MYG1NMrUFTQdNqrOWVcIhYZhIdBwqJlqylJAJS7Jm7XvHpw-ejuAP-sJrL693uklliSVuRL1iSf2amXTht9nDFEPNhh0Dkac5qC5kFVRV6pmCS1W1CQhgsfuoTdnerFJH_Rqk15sWqLJplT26n7C3AzYPhT98yUBr1egg0lDEi7ou6-pg0weClEUC_FuJTCpdrLodTAWR4Ot9Wiibif7_x3-AuYLsaM</recordid><startdate>20130701</startdate><enddate>20130701</enddate><creator>Wenk, Christiane H.F.</creator><creator>Ponce, Frédérique</creator><creator>Guillermet, Stéphanie</creator><creator>Tenaud, Corinne</creator><creator>Boturyn, Didier</creator><creator>Dumy, Pascal</creator><creator>Watrelot-Virieux, Dorothée</creator><creator>Carozzo, Claude</creator><creator>Josserand, Véronique</creator><creator>Coll, Jean-Luc</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-2530-0299</orcidid><orcidid>https://orcid.org/0000-0002-7660-763X</orcidid><orcidid>https://orcid.org/0000-0003-0741-0654</orcidid><orcidid>https://orcid.org/0000-0002-8980-3250</orcidid><orcidid>https://orcid.org/0000-0001-6733-3801</orcidid><orcidid>https://orcid.org/0000-0002-2453-3552</orcidid></search><sort><creationdate>20130701</creationdate><title>Near-infrared optical guided surgery of highly infiltrative fibrosarcomas in cats using an anti-αvß3 integrin molecular probe</title><author>Wenk, Christiane H.F. ; 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subjects	Animals Cat Diseases - metabolism Cat Diseases - surgery Cats Chemical Sciences Female Fibrosarcoma Fibrosarcoma - metabolism Fibrosarcoma - radiotherapy Fibrosarcoma - surgery Fibrosarcoma - veterinary fluorescence Fluorescence imaging Fluorescent Antibody Technique - methods Fluorescent Antibody Technique - veterinary image analysis Image Enhancement - methods Integrin alphaVbeta3 - analysis Integrin alphaVbeta3 - metabolism integrins Male Molecular Probes Oncology RGD Spectroscopy, Near-Infrared - methods Spectroscopy, Near-Infrared - veterinary Surgery Tissue Distribution
title	Near-infrared optical guided surgery of highly infiltrative fibrosarcomas in cats using an anti-αvß3 integrin molecular probe
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