Brain Networks are Independently Modulated by Donepezil, Sleep, and Sleep Deprivation

• Published in: Brain topography 2018-05, Vol.31 (3), p.380-391
• Main Authors: Wirsich, Jonathan, Rey, Marc, Guye, Maxime, Bénar, Christian, Lanteaume, Laura, Ridley, Ben, Confort-Gouny, Sylviane, Cassé-Perrot, Catherine, Soulier, Elisabeth, Viout, Patrick, Rouby, Franck, Lefebvre, Marie-Noëlle, Audebert, Christine, Truillet, Romain, Jouve, Elisabeth, Payoux, Pierre, Bartrés-Faz, David, Bordet, Régis, Richardson, Jill C., Babiloni, Claudio, Rossini, Paolo Maria, Micallef, Joelle, Blin, Olivier, Ranjeva, Jean-Philippe
• Format: Article
• Language: English
• Subjects: Adult; Bioengineering; Biomedical and Life Sciences; Biomedicine; Brain - diagnostic imaging; Brain - drug effects; Brain - physiopathology; Brain Mapping; Cognitive ability; Computer Science; Cortex; Donepezil; Donepezil - pharmacology; EEG; Electroencephalography; Functional magnetic resonance imaging; Humans; Imaging; Life Sciences; Magnetic Resonance Imaging; Male; Medical Imaging; Medical innovations; Memantine; Nerve Net - diagnostic imaging; Nerve Net - drug effects; Nerve Net - physiopathology; Neural networks; Neurodegenerative diseases; Neurology; Neurosciences; Nootropic Agents - pharmacology; Original Paper; Psychiatry; Sleep - physiology; Sleep deprivation; Sleep Deprivation - diagnostic imaging; Sleep Deprivation - physiopathology; Statistical analysis; Vigilance
• ISSN: 0896-0267; 1573-6792
• DOI: 10.1007/s10548-017-0608-5

Resting-state connectivity has been widely studied in the healthy and pathological brain. Less well-characterized are the brain networks altered during pharmacological interventions and their possible interaction with vigilance. In the hopes of finding new biomarkers which can be used to identify cortical activity and cognitive processes linked to the effects of drugs to treat neurodegenerative diseases such as Alzheimer’s disease, the analysis of networks altered by medication would be particularly interesting. Eleven healthy subjects were recruited in the context of the European Innovative Medicines Initiative ‘PharmaCog’. Each underwent five sessions of simultaneous EEG-fMRI in order to investigate the effects of donepezil and memantine before and after sleep deprivation (SD). The SD approach has been previously proposed as a model for cognitive impairment in healthy subjects. By applying network based statistics (NBS), we observed altered brain networks significantly linked to donepezil intake and sleep deprivation. Taking into account the sleep stages extracted from the EEG data we revealed that a network linked to sleep is interacting with sleep deprivation but not with medication intake. We successfully extracted the functional resting-state networks modified by donepezil intake, sleep and SD. We observed donepezil induced whole brain connectivity alterations forming a network separated from the changes induced by sleep and SD, a result which shows the utility of this approach to check for the validity of pharmacological resting-state analysis of the tested medications without the need of taking into account the subject specific vigilance.