Combination of baseline FDG PET/CT total metabolic tumour volume and gene expression profile have a robust predictive value in patients with diffuse large B-cell lymphoma

Purpose This study evaluated the predictive significance of total metabolic tumour volume (TMTV) measured on baseline FDG PET/CT and its value in addition to gene expression profiling using a new method of gene analysis (rapid reverse transcriptase multiplex ligation-dependent probe amplification as...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2018-05, Vol.45 (5), p.680-688
Main Authors: Toledano, Mathieu Nessim, Desbordes, P., Banjar, A., Gardin, I., Vera, P., Ruminy, P., Jardin, F., Tilly, H., Becker, S.
Format: Article
Language:English
Subjects:
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
B-cell lymphoma
Cardiology
Disease-Free Survival
Female
Fluorodeoxyglucose F18
Gene expression
Gene Expression Profiling
Genotype & phenotype
Humans
Imaging
Life Sciences
Lymphocytes B
Lymphoma
Lymphoma, Large B-Cell, Diffuse - diagnostic imaging
Lymphoma, Large B-Cell, Diffuse - drug therapy
Lymphoma, Large B-Cell, Diffuse - genetics
Male
Medical prognosis
Medicine
Medicine & Public Health
Metabolism
Middle Aged
Multivariate analysis
Neoplasm Recurrence, Local
Nuclear Medicine
Oncology
Original Article
Orthopedics
Patients
Phenotypes
Positron emission tomography
Positron Emission Tomography Computed Tomography
Prognosis
Radiology
Retrospective Studies
RNA-directed DNA polymerase
Survival
Transcriptome
Tumor Burden
Tumors
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Summary:Purpose This study evaluated the predictive significance of total metabolic tumour volume (TMTV) measured on baseline FDG PET/CT and its value in addition to gene expression profiling using a new method of gene analysis (rapid reverse transcriptase multiplex ligation-dependent probe amplification assay, RT-MLPA) in patients with diffuse large B-cell lymphoma treated with R-CHOP or R-CHOP-like chemotherapies. Methods The analysis included 114 patients. TMTV was measured using a 41% SUVmax threshold and tumours were classified into GCB or ABC subtypes according to the RT-MLPA assay. Results The median follow-up was 40 months. the 5-year progression-free survival (PFS) was 54% and the 5-year overall survival (OS) was 62%. The optimal TMTV cut-off value was 261 cm 3 . In 59 patients with a high TMTV the 5-year PFS and OS were 37% and 39%, respectively, in comparison with 72% and 83%, respectively, in 55 patients with a low TMTV ( p  = 0.0002 for PFS, p  
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-017-3907-x