Both sunitinib and sorafenib are effective treatments for pheochromocytoma in a xenograft model

Highlights • Sunitinib and sorafenib inhibit the growth of pheochromocytoma cell xenografts. • Sunitinib and sorafenib inhibit tumor neo-angiogenesis in pheochromocytoma cell xenografts. • Sunitinib and sorafenib induce apoptosis in pheochromocytoma cell xenografts. • Sunitinib and sorafenib decreas...

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Bibliographic Details
Published in:Cancer letters 2014-10, Vol.352 (2), p.236-244
Main Authors: Denorme, M, Yon, L, Roux, C, Gonzalez, B.J, Baudin, E, Anouar, Y, Dubessy, C
Format: Article
Language:English
Subjects:
Administration, Oral
Adrenal Gland Neoplasms - blood supply
Adrenal Gland Neoplasms - drug therapy
Adrenal Gland Neoplasms - enzymology
Adrenal Gland Neoplasms - pathology
Angiogenesis
Angiogenesis Inhibitors - administration & dosage
Angiogenesis Inhibitors - pharmacology
Animals
Apoptosis
Apoptosis - drug effects
Cell Survival - drug effects
Dose-Response Relationship, Drug
Drug dosages
FDA approval
Gene expression
Hematology, Oncology and Palliative Medicine
Heterografts
Indoles - administration & dosage
Indoles - pharmacology
Kinases
Life Sciences
Liver cancer
Male
Mice
Mice, Nude
Mortality
Mutation
Neoplasm Transplantation
Neovascularization, Pathologic
Niacinamide - administration & dosage
Niacinamide - analogs & derivatives
Niacinamide - pharmacology
PC12 Cells
Phenylurea Compounds - administration & dosage
Phenylurea Compounds - pharmacology
Pheochromocytoma
Pheochromocytoma - blood supply
Pheochromocytoma - drug therapy
Pheochromocytoma - enzymology
Pheochromocytoma - pathology
Protein Kinase Inhibitors - administration & dosage
Protein Kinase Inhibitors - pharmacology
Pyrroles - administration & dosage
Pyrroles - pharmacology
Rats
Sorafenib
Studies
Sunitinib
Therapy
Time Factors
Tumor Burden - drug effects
Tumors
Vascular endothelial growth factor
Xenograft model
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Summary:Highlights • Sunitinib and sorafenib inhibit the growth of pheochromocytoma cell xenografts. • Sunitinib and sorafenib inhibit tumor neo-angiogenesis in pheochromocytoma cell xenografts. • Sunitinib and sorafenib induce apoptosis in pheochromocytoma cell xenografts. • Sunitinib and sorafenib decrease the viability of PC12 cells. • Sunitinib, but not sorafenib, exerts a pro-apoptotic effect in PC12 cells.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2014.07.005