Palladium‐Catalyzed Cross‐Coupling/Annulation Cascade for Synthesis of 9‐Hydroxy and 9‐Aminofluorenes

9‐Hydroxyfluorenes are easily synthesized via a tandem Suzuki/phenolic aldolisation sequence. This process was extended to 9‐aminofluorenes by simply adding various amines as third partners. X‐ray structures and NMR studies confirmed the presence of intermolecular O−H ⋅ ⋅ ⋅ N hydrogen bonding....

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Published in:Advanced synthesis & catalysis 2018-01, Vol.360 (2), p.235-241
Main Authors: François, Benjamin, Szczubelek, Luc, Berrée, Fabienne, Roisnel, Thierry, Carboni, Bertrand
Format: Article
Language:English
Subjects:
Amines
Betti bases
cascade process
Chemical reactions
Chemical Sciences
Chemical synthesis
Cross coupling
fluorene
Hydrogen bonding
Mannich reaction
NMR
Nuclear magnetic resonance
Organic chemistry
Palladium
Suzuki coupling
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cited_by cdi_FETCH-LOGICAL-c4286-70558082502857726e1042c053942b7f557e08916461880e1851c0c2c3a5f6963
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description 9‐Hydroxyfluorenes are easily synthesized via a tandem Suzuki/phenolic aldolisation sequence. This process was extended to 9‐aminofluorenes by simply adding various amines as third partners. X‐ray structures and NMR studies confirmed the presence of intermolecular O−H ⋅ ⋅ ⋅ N hydrogen bonding.
doi_str_mv 10.1002/adsc.201701146
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source Wiley-Blackwell Read & Publish Collection
subjects Amines
Betti bases
cascade process
Chemical reactions
Chemical Sciences
Chemical synthesis
Cross coupling
fluorene
Hydrogen bonding
Mannich reaction
NMR
Nuclear magnetic resonance
Organic chemistry
Palladium
Suzuki coupling
title Palladium‐Catalyzed Cross‐Coupling/Annulation Cascade for Synthesis of 9‐Hydroxy and 9‐Aminofluorenes
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