Cellular localisation of a water-soluble fullerene derivative

Fullerenes are a new class of compounds with potential uses in biology and medicine and many insights were made in the knowledge of their interaction with various biological systems. However, their interaction with organised living systems as well as the site of their potential action remains unclea...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2002-05, Vol.294 (1), p.116-119
Main Authors: Foley, Sarah, Crowley, Colin, Smaihi, Monique, Bonfils, Claude, Erlanger, Bernard F, Seta, Patrick, Larroque, Christian
Format: Article
Language:English
Subjects:
Animals
Carbon - chemistry
Carbon - metabolism
Cell Membrane - metabolism
Cells, Cultured
Chemical Sciences
COS Cells
Drug Delivery Systems
Fluorescent Antibody Technique, Indirect
Fullerenes
Humans
Magnetic Resonance Spectroscopy
Microscopy, Fluorescence
Mitochondria - metabolism
Solubility
Structure-Activity Relationship
Water
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Summary:Fullerenes are a new class of compounds with potential uses in biology and medicine and many insights were made in the knowledge of their interaction with various biological systems. However, their interaction with organised living systems as well as the site of their potential action remains unclear. In this work, we have demonstrated that a fullerene derivative could cross the external cellular membrane and it localises preferentially to the mitochondria. We propose that our finding supports the potential use of fullerenes as drug delivery agents as their structure mimics that of clathrin known to mediate endocytosis.
ISSN:0006-291X
1090-2104
DOI:10.1016/S0006-291X(02)00445-X