Prevalence of malnutrition in adult patients previously treated with allogeneic hematopoietic stem-cell transplantation

Summary Introduction Malnutrition is common after allogeneic hematopoietic stem cell transplantation (allo-HSCT), and is a well-known prognostic factor for survival. The nutritional status of patients in a long term after allo-HSCT is less well documented. The main objective of this study was to eva...

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Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2018-04, Vol.37 (2), p.739-745
Main Authors: Brotelle, Thibault, Lemal, Richard, Cabrespine, Aurélie, Combal, Cécile, Hermet, Eric, Ravinet, Aurélie, Bay, Jacques-Olivier, Bouteloup, Corinne
Format: Article
Language:English
Subjects:
Body composition
Cohort Studies
Female
Gastroenterology and Hepatology
Hemato-oncology
Hematology
Hematopoietic Stem Cell Transplantation
Human health and pathology
Humans
Life Sciences
Male
Malnutrition - diagnosis
Malnutrition - epidemiology
Middle Aged
Muscle mass
Muscle strength
Nutrition Assessment
Nutritional Status
Postoperative Complications - diagnosis
Postoperative Complications - epidemiology
Prevalence
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Summary:Summary Introduction Malnutrition is common after allogeneic hematopoietic stem cell transplantation (allo-HSCT), and is a well-known prognostic factor for survival. The nutritional status of patients in a long term after allo-HSCT is less well documented. The main objective of this study was to evaluate the prevalence of malnutrition in adult patients who underwent allo-HSCT more than one year ago. Secondary objectives were to assess body composition, muscle strength, and factors associated with malnutrition. Patients & methods All allo-HSCT patients admitted into the University Hospital of Clermont-Ferrand between 1st January 1985 and 31st December 2012 were screened. Clinical and biological nutritional assessments included anthropometric measurements, serum nutritional proteins, body composition assessed by bioelectrical impedance, and upper-limb muscle strength (MS) measured by dynamometry. Hematological and nutritional data during and after hospital stay for allo-HSCT were retrospectively collected. Results Eighty four allo-HSCT patients (52% men; mean age 54.4 ± 12.5 years) were enrolled. Average follow-up after allo-HSCT was 56.4 ± 47.5 months. Prevalence of malnutrition at the end of follow-up was 20%. Compared to well-nourished patients (WN group), undernourished patients (UN group) at the end of follow-up were significantly more likely to be undernourished (50% vs. 21%, p  = 0.04) at hospital admission, and to have a Nutritional Risk Index of
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2017.03.016