Red light photodynamic therapy for actinic keratosis using 37 J/cm 2 : fractionated irradiation with 12.3 mW/cm 2 after 30 minutes incubation time compared to standard continuous irradiation with 75 mW/cm 2 after three hours incubation time using a mathematical modeling

• Published in: Lasers in surgery and medicine 2017-04
• Main Authors: Vignion-Dewalle, Anne-Sophie, Baert, Grégory, Devos, Laura, Thecua, Elise, Vicentini, Claire, Mortier, Laurent, Mordon, Serge
• Format: Article
• Language: English
• Subjects: Cancer; Life Sciences
• ISSN: 0196-8092; 1096-9101

Photodynamic therapy (PDT) is an emerging treatment modality for various diseases, especially for dermatological conditions. Although the standard PDT protocol for the treatment of actinic keratoses in Europe has shown to be effective, treatment-associated pain is often observed in patients. Different modifications to this protocol attempted to decrease pain have been investigated. The decrease in fluence rate seems to be a promising solution. Moreover, it has been suggested that light fractionation significantly increases the efficacy of PDT. Based on a flexible light-emitting textile, the FLEXITHERALIGHT device specifically provides a fractionated illumination at a fluence rate more than six times lower than that of the standard protocol. In a recently completed clinical trial of PDT for the treatment of actinic keratosis, the non-inferiority of a protocol involving illumination with the FLEXITHERALIGHT device after a short incubation time and referred to as the FLEXITHERALIGHT protocol has been assessed compared to the standard protocol. In this paper, we propose a comparison of the two above mentioned 635 nm red light protocols with 37 J/cm 2 in the PDT treatment of actinic keratosis: the standard protocol and the FLEXITHERALIGHT one through a mathematical modeling, which slightly differs from the one we have already published. This comparison performed in terms of the local damage induced by the therapy demonstrates that the FLEXITHERALIGHT protocol with lower fluence rate, light fractionation and shorter incubation time is somewhat less efficient than the standard protocol. Nevertheless, from the clinical trial results, the FLEXITHERALIGHT protocol results in non-inferior response rates compared to the standard protocol. This finding raises the question of whether the PDT local damage achieved by the FLEXITHERALIGHT protocol (respectively, the standard protocol) is sufficient (respectively, excessive) to destroy 2 actinic keratosis cells…