Heterogeneity of Expression of IgA Receptors by Human, Mouse, and Rat Eosinophils

IgA is the most abundant class of Abs at mucosal surfaces where eosinophils carry out many of their effector functions. Most of the known IgA-mediated functions require interactions with IgA receptors, six of which have been identified in humans. These include the IgA FcR FcalphaRI/CD89 and the rece...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2005-01, Vol.174 (2), p.628-635
Main Authors: Decot, Veronique, Woerly, Gaetane, Loyens, Marc, Loiseau, Sylvie, Quatannens, Brigitte, Capron, Monique, Dombrowicz, David
Format: Article
Language:English
Subjects:
Animals
Asialoglycoprotein Receptor - biosynthesis
Asialoglycoprotein Receptor - blood
Cells, Cultured
Cellular Biology
Eosinophils - immunology
Eosinophils - metabolism
Humans
Immunoglobulin A - blood
Life Sciences
Mice
Mice, Inbred BALB C
Mice, Transgenic
Protein Binding - immunology
Rats
Rats, Inbred BN
Receptors, Fc - biosynthesis
Receptors, Fc - blood
Receptors, Polymeric Immunoglobulin - biosynthesis
Receptors, Polymeric Immunoglobulin - blood
Receptors, Transferrin - biosynthesis
Receptors, Transferrin - blood
Subcellular Processes
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Summary:IgA is the most abundant class of Abs at mucosal surfaces where eosinophils carry out many of their effector functions. Most of the known IgA-mediated functions require interactions with IgA receptors, six of which have been identified in humans. These include the IgA FcR FcalphaRI/CD89 and the receptor for the secretory component, already identified on human eosinophils, the polymeric IgR, the Fcalpha/muR, asialoglycoprotein (ASGP)-R, and transferrin (Tf)R/CD71. In rodents, the existence of IgA receptors on mouse and rat eosinophils remains unclear. We have compared the expression and function of IgA receptors by human, rat, and mouse eosinophils. Our results show that human eosinophils express functional polymeric IgR, ASGP-R, and TfR, in addition to CD89 and the receptor for the secretory component, and that IgA receptors are expressed by rodent eosinophils. Indeed, mouse eosinophils expressed only TfR, whereas rat eosinophils expressed ASGP-R and CD89 mRNA. These results provide a molecular basis for the differences observed between human, rat, and mouse regarding IgA-mediated immunity.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.174.2.628