Impact of psychological factors on the health-related quality of life of patients treated for pulmonary arterial hypertension

• Published in: Journal of psychosomatic research 2018-02, Vol.105, p.45-51
• Main Authors: Halimi, Laurence, Marin, Grégory, Molinari, Nicolas, Gamez, Anne-Sophie, Boissin, Clément, Suehs, Carey M., Vachier, Isabelle, Bourdin, Arnaud
• Format: Article
• Language: English
• Subjects: 6-min walk distance; Anxiety; Anxiety-depression; Catheterization; Clinical information; Coping; Coping strategies; Delayed; Diagnosis; Etiology; Health status; Health-related quality of life; Hemodynamics; Hypertension; Life Sciences; Life threatening; Medical diagnosis; Medical prognosis; Mental depression; Mental health; Multivariate analysis; Oxygen; Oxygen desaturation; Psychological aspects; Psychosocial factors; Pulmonary arterial hypertension; Pulmonary hypertension; Qualitative research; Quality of life; Questionnaires; Saturation; Trait anxiety
• ISSN: 0022-3999; 1879-1360
• DOI: 10.1016/j.jpsychores.2017.12.003

Pulmonary arterial hypertension (PAH) is a rare and life-threatening disease well-marked by under diagnosis, delayed diagnosis and atypical treatments. Few data are available on the quality of life (QoL) and psychosocial characteristics of patients with PAH. Our aim is to describe the impact of psychological factors on the health-related quality of life (HRQoL) of treated PAH patients in a cross-sectional study. Consecutive patients presenting at our Competency Centre for PAH were recruited. The aetiology, New York Heart Association (NYHA) stage, haemodynamics, 6-min walk distance (6MWD), delta SPO2 (Pulse oximeter oxygen saturation; baseline lowest value during 6-min walk test (6MWT), current treatments and psychological history were recorded. HRQoL, anxiety, depression and coping strategies were explored using self-administered questionnaires (SF-36, HADS, STAI-Y, CHIP and WCC). A total of 55 patients were included. The HRQoL of PAH patients was poor with altered results on several scales. Anxiety and depression were high and coping was focused on medical information strategies. Multivariate analysis indicated a positive relationship between 6MWD and the Physical Composite Score for QoL (p=0.004), as well as a negative relationship between delta SPO2 and the Mental Composite Score (p=0.02), irrespective of other known prognostic factors (such as haemodynamics at right heart catheterization). Depression and Trait-Anxiety were associated with a lower physical (p=0.001) and mental (p