Identification of Most Aggressive Carcinoma Among Patients Diagnosed With Prostate Cancer Using Mathematical Modeling of Prostate-Specific Antigen Increases

Micro-Abstract Mathematical models of prostate-specific antigen (PSA) longitudinal growth can help differentiate aggressive and indolent prostate cancer at diagnosis. The PSA kinetics of 62 patients with benign prostatic hyperplasia and 149 patients with prostate cancer were modeled. A modeled PSA g...

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Bibliographic Details
Published in:Clinical genitourinary cancer 2016-06, Vol.14 (3), p.210-217.e1
Main Authors: de Charry, Félicité, Colomban, Olivier, You, Benoit, Ruffion, Alain, Paparel, Philippe, Wilbaux, Mélanie, Tod, Michel, Freyer, Gilles, Perrin, Paul
Format: Article
Language:English
Subjects:
Aged
Cancer
Decision support techniques
Disease-Free Survival
Hematology, Oncology and Palliative Medicine
Humans
Kallikreins - blood
Kaplan-Meier Estimate
Life Sciences
Male
Middle Aged
Proportional Hazards Models
Prostate - pathology
Prostate-Specific Antigen - blood
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - mortality
Prostrate neoplasms
PSA kinetics
Retrospective Studies
Risk Assessment
Theoretical
Tumor Burden
Urology
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Summary:Micro-Abstract Mathematical models of prostate-specific antigen (PSA) longitudinal growth can help differentiate aggressive and indolent prostate cancer at diagnosis. The PSA kinetics of 62 patients with benign prostatic hyperplasia and 149 patients with prostate cancer were modeled. A modeled PSA growth rate kinetic parameter (RHO1) was associated with the probability of the D'Amico high-risk group and lower relapse-free survival.
ISSN:1558-7673
1938-0682
DOI:10.1016/j.clgc.2015.12.006