Prognostic value of serum PIIINP, MMP1 and TIMP1 levels in hypertensive patients: a community-based prospective cohort study

• Published in: Fundamental & clinical pharmacology 2013-10, Vol.27 (5), p.572-580
• Main Authors: Agrinier, Nelly, Thilly, Nathalie, Boivin, Jean-Marc, Dousset, Brigitte, Alla, François, Zannad, Faiez
• Format: Article
• Language: English
• Subjects: Aged; Arterial hypertension. Arterial hypotension; Biological and medical sciences; biological markers; Biomarkers; Biomarkers - blood; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiovascular Diseases; Cardiovascular Diseases - epidemiology; Cohort Studies; Collagen Type III; Collagen Type III - blood; Essential Hypertension; extracellular matrix; Female; Fibrosis; Follow-Up Studies; France; France - epidemiology; Heart Ventricles; Heart Ventricles - pathology; Heart Ventricles - physiopathology; Humans; Hypertension; Hypertension - blood; Hypertension - diagnosis; Hypertension - pathology; Hypertension - physiopathology; hypertrophy; Hypertrophy, Left Ventricular; Hypertrophy, Left Ventricular - epidemiology; Hypertrophy, Left Ventricular - etiology; Hypertrophy, Left Ventricular - pathology; Hypertrophy, Left Ventricular - physiopathology; left ventricular; Life Sciences; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 1 - blood; Medical sciences; Middle Aged; Mortality; Peptide Fragments; Peptide Fragments - blood; Pharmacology. Drug treatments; Procollagen; Procollagen - blood; Prognosis; Proportional Hazards Models; Prospective Studies; Risk; Santé publique et épidémiologie; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-1 - blood
• ISSN: 0767-3981; 1472-8206
• DOI: 10.1111/j.1472-8206.2012.01053.x

The purpose of this study was to examine the prognostic value of serum ECM biomarkers in hypertensive patients with no history of cardiovascular events. In a community‐based cohort study of 125 hypertensive patients free of cardiovascular events, we collected clinical data and blood samples to assess serum levels of amino‐terminal propeptide of type III procollagen (PIIINP), matrix metalloproteinase type 1(MMP1) and tissue inhibitor of MMPs type 1(TIMP1). Left ventricular hypertrophy (LVH) was assessed using the ECG Cornell product. Patients were followed up for death or cardiovascular hospitalisation. We used Cox regression models to assess the prognostic value of ECM biomarkers. The sample included 60.8% women; the mean (±SD) age was 62.9 (±11.4) years. Patients were followed up for a median of 5.5 years, during which 23 events (five deaths) occurred. PIIINP (3.2 ± 1.0 vs. 2.6 ± 0.8 μg/L, P = 0.001) and TIMP1 (886 ± 168 vs. 751 ± 202 μg/L, P