Synthesis, characterization and molecular modeling of binuclear Pd(II) and Ir(IV) complexes with bis [4-hydroxy-6-methyl-3-{(1E)-N-[2-(ethylamino)ethyl]ethanimidoyl}-2H-pyran-2-one]: Application to detection of glucose

• Published in: Journal of molecular structure 2018-10, Vol.1170, p.119-130
• Main Authors: Ait-Ramdane-Terbouche, Chafia, Terbouche, Achour, Khalfaoui, Massaab, Douib, Chahira-Lamya, Lakhdari, Houria, Lerari, Djahida, Bachari, Khaldoun, Mezaoui, Djillali, Guegan, Jean-Paul, Hauchard, Didier
• Format: Article
• Language: English
• Subjects: Biological activities; Chemical Sciences; Chronoamperometric glucose detection; DFT; Pd(II) and Ir(IV) complexes; Schiff base; Stability constants
• ISSN: 0022-2860; 1872-8014; 0022-2860
• DOI: 10.1016/j.molstruc.2018.05.075

Two binuclear Pd (II) and Ir(IV) complexes with new bis [4-hydroxy-6-methyl-3-{(1E)-N-[2-(ethylamino) ethyl] ethanimidoyl}-2H-pyran-2-one] ligand (Schiff base: L) have been prepared and characterized by elemental analysis, ESI-MS, conductivity, NMR (1H NMR, 13C NMR, COSY-NMR, HMBC-NMR and HSQC-NMR), EPR, FT-IR, ATR, UV–Visible spectra and cyclic voltammetry. Both antioxidant and antimicrobial activities were studied; the stability constants of the metal complexes and their interactions with glucose were estimated using spectrophotometric method. In addition, the detection of glucose using Pd(II) and Ir(IV) complexes was investigated using cavity microelectrode (CME) by chronoamperometric method. The characterization results and the molecular parameters were determined using DFT technique; a square planar geometry around Pd (II) and an octahedral geometry around Ir(IV) was found. The antioxidant measurements showed that the ligand and its complexes exhibited remarkable activity, and the antimicrobial studies revealed that all compounds are biologically active for some bacteria and fungi. Electrochemical measurements showed the presence of sensitive responses towards glucose using both Pd(II) and Ir(IV) complexes; these results were found to be higher than other materials around glucose concentration range of 0–4 mM. [Display omitted] •Two binuclear Pd(II) and Ir(IV) complexes with new ligand were synthesized and characterized.•The optimized geometries of the complexes were studied by DFT technique.•The stability constants of Pd(II) and Ir(IV) complexes and their interaction with glucose were examined.•The antioxidant and antibacterial activities were investigated.•Pd(II) and Ir(IV) complexes are suitable materials for the determination of glucose.