Assessment of Compressive Raman versus Hyperspectral Raman for Microcalcification Chemical Imaging

We experimentally implement a compressive Raman technology (CRT) that incorporates chemometric analysis directly into the spectrometer hardware by means of a digital micromirror device (DMD). The DMD is a programmable optical filter on which optimized binary filters are displayed. The latter are gen...

Full description

Saved in:
Bibliographic Details
Published in:Analytical chemistry (Washington) 2018-06, Vol.90 (12), p.7197-7203
Main Authors: Scotté, Camille, de Aguiar, Hilton B, Marguet, Didier, Green, Ellen Marie, Bouzy, Pascaline, Vergnole, Sébastien, Winlove, Charles Peter, Stone, Nicholas, Rigneault, Hervé
Format: Article
Language:English
Subjects:
Analytical chemistry
Breast cancer
Calcification
Chemical Sciences
Chemistry
Cramer-Rao bounds
Engineering Sciences
Hyperspectral imaging
Lower bounds
Medical imaging
Optical filters
Optics
Organic chemistry
Photonic
Scientific imaging
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We experimentally implement a compressive Raman technology (CRT) that incorporates chemometric analysis directly into the spectrometer hardware by means of a digital micromirror device (DMD). The DMD is a programmable optical filter on which optimized binary filters are displayed. The latter are generated with an algorithm based on the Cramer-Rao lower bound. We compared the developed CRT microspectrometer with two conventional state-of-the-art Raman hyperspectral imaging systems on samples mimicking microcalcifications relevant for breast cancer diagnosis. The CRT limit of detection significantly improves, when compared to the CCD based system, and CRT ultimately allows 100× and 10× faster acquisition speeds than the CCD- and EMCCD-based systems, respectively.
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.7b05303